NCBI Description
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
Uniprot Description
PTP4A2: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. Belongs to the protein-tyrosine phosphatase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 1p35
Cellular Component: cytoplasm; early endosome; plasma membrane
Molecular Function: prenylated protein tyrosine phosphatase activity
Product Notes
The PTP4A2 ptp4a2 (Catalog #
AAA637048) is an Active Protein produced from Recombinant, Human from E Coli and is intended for research purposes only. The product is available for immediate purchase. The PRL-2, aa2-167, catalytic domain Recombinant, Human (Protein tyrosine phosphatase, Phosphatase of regenerating liver-2) reacts with Human and may cross-react with other species as described in the data sheet. useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors. Researchers should empirically determine the suitability of the PTP4A2 ptp4a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"PRL-2, aa2-167, catalytic domain Recombinant, Active Protein" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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