SDS-Page
(3ug by SDS-Page under reducing condition and visualized by coomassie blue stain.)
DSCR1 recombinant protein
DSCR1 isoform b, 1-117aa, Human, E Coli
Gene Names
RCAN1; CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78
Applications
SDS-Page
Purity
> 90% by SDS-PAGE
Synonyms
DSCR1; DSCR1 isoform b; 1-117aa; Human; E Coli; Down syndrome candidate region 1; Down syndrome critical region protein 1; adapt78 protein; calcipressin 1; Calcipressin 1 isoform b; DSCR1 recombinant protein
Host
E Coli
Purity/Purification
> 90% by SDS-PAGE
Form/Format
In 20mM Tris 7.5, 0.1M NaCl, 1mM DTT
Concentration
1 mg/ml (determined by Bradford assay) (varies by lot)
Sequence
MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS
Sequence Length
1-117aa
Applicable Applications for DSCR1 recombinant protein
SDS-PAGE
Tag
Non-Tagged
Preparation and Storage
Can be stored at 2-8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing nad thawing cycles.
SDS-Page
(3ug by SDS-Page under reducing condition and visualized by coomassie blue stain.)
SDS-Page
(3ug by SDS-Page under reducing condition and visualized by coomassie blue stain.)
Related Product Information for DSCR1 recombinant protein
The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a. Recombinant human DSCR1 was expressed in E Coli and purified by using conventional chromatography techniques.
Product Categories/Family for DSCR1 recombinant protein
References
Hesser BA., et al. (2004) Blood. 104 (1):149-58; Harris CD., et al. (2007) FEBS J. 274 (7):1715-24.;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
13kDa (117aa), confirmed by MALDI-TOF.
NCBI Official Full Name
calcipressin-1 isoform b
NCBI Official Synonym Full Names
regulator of calcineurin 1
NCBI Official Symbol
RCAN1
NCBI Official Synonym Symbols
CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78
NCBI Protein Information
calcipressin-1
UniProt Protein Name
Calcipressin-1
UniProt Gene Name
RCAN1
UniProt Synonym Gene Names
ADAPT78; CSP1; DSC1; DSCR1; MCIP1
NCBI Description
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Uniprot Description
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Research Articles on DSCR1
Similar Products
Product Notes
The DSCR1 rcan1 (Catalog #AAA203113) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's DSCR1 can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE. Researchers should empirically determine the suitability of the DSCR1 rcan1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS. It is sometimes possible for the material contained within the vial of "DSCR1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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