Mouse recombination signal binding protein for immunoglobulin kappa J region ELISA Kit | RBPJ elisa kit

Mouse Recombining binding protein suppressor of hairless, RBPJ ELISA Kit

Cat. Num. AAA9319486

• Gene Names: Rbpj; CBF1; RBP-J; RBPjk; Igkjrb; Rbpsuh; Igkrsbp; AI843960; RBP-J kappa
• Reactivity: Mouse
• Synonyms: recombination signal binding protein for immunoglobulin kappa J region; Mouse Recombining binding protein suppressor of hairless; RBPJ ELISA Kit; Mouse Recombining binding protein suppressor of hairless (RBPJ) ELISA kit; CBF1; IGKJRB; IGKJRB1; KBF2; MGC61669; RBP-J; RBPJK; RBPSUH; SUH; csl; H-2K binding factor-2; OTTHUMP00000123441; immunoglobulin kappa J region recombination signal binding protein 1; recombining bindi; RBPJ elisa kit

• Reactivity: Mouse
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Body fluids, tissue homogenates, secretions or feces samples
• Assay Type: Quantitative Sandwich
• Detection Range: 3.12 ng/ml - 100 ng/ml
• Sensitivity: 1.0 ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for RBPJ elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of RBPJ (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 124286787
• NCBI GeneID: 19664
• NCBI Accession #: NP_001074396.1
• NCBI GenBank Nucleotide #: NM_001080927.2
• UniProt Accession #: P31266; Q80UN8; Q8C4Z3
• Molecular Weight: 58,537 Da
• NCBI Official Full Name: recombining binding protein suppressor of hairless isoform 2
• NCBI Official Synonym Full Names: recombination signal binding protein for immunoglobulin kappa J region
• NCBI Official Symbol: Rbpj
• NCBI Official Synonym Symbols: CBF1; RBP-J; RBPjk; Igkjrb; Rbpsuh; Igkrsbp; AI843960; RBP-J kappa
• NCBI Protein Information: recombining binding protein suppressor of hairless
• UniProt Protein Name: Recombining binding protein suppressor of hairless
• Protein Family: Recombining binding protein suppressor of hairless
• UniProt Gene Name: Rbpj
• UniProt Synonym Gene Names: Igkjrb1; Igkrsbp; Rbpsuh
• UniProt Entry Name: SUH_MOUSE

Uniprot Description

RBPJ: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Interacts with activated NOTCH1, NOTCH2 or NOTCH3. Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR1. Interacts with EP300, MAML1 and PTF1A. Interacts with Epstein-Barr virus EBNA2, EBNA3, EBNA4 and EBNA6. Interacts with RITA/C12orf52, leading to nuclear export, prevent the interaction between RBPJ and NICD product and subsequent down-regulation of the Notch signaling pathway. Belongs to the Su(H) family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Transcription factor

Cellular Component: transcription factor complex; protein complex; cell; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; protein complex binding; protein N-terminus binding; chromatin binding; transcription factor binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; somatic stem cell maintenance; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; heart development; myeloid dendritic cell differentiation; sebaceous gland development; negative regulation of smooth muscle cell migration; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; negative regulation of ossification; hemopoiesis; angiogenesis; heart looping; regulation of timing of cell differentiation; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation; Notch signaling pathway; epidermal cell fate specification; somitogenesis; cell fate commitment; transcription, DNA-dependent; hair follicle maturation; humoral immune response; activation of Notch receptor target transcription factor; regulation of transcription from RNA polymerase II promoter; keratinocyte differentiation; negative regulation of cell differentiation; inflammatory response to antigenic stimulus; pituitary gland development; regulation of gene expression; B cell differentiation; defense response to bacterium; epithelial to mesenchymal transition; blood vessel remodeling; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; auditory receptor cell fate commitment