Human retinoblastoma-like 2 (p130) ELISA Kit | RBL2 elisa kit
Human Retinoblastoma-like protein 2, RBL2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Rb-like 2: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. Belongs to the retinoblastoma protein (RB) family.
Protein type: Tumor suppressor; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16q12.2
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of cell cycle; regulation of lipid kinase activity; chromatin modification; mitotic cell cycle
Research Articles on RBL2
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Product Notes
The Human RBL2 rbl2 (Catalog #AAA9319319) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319319 ELISA Kit recognizes Human RBL2. It is sometimes possible for the material contained within the vial of "retinoblastoma-like 2 (p130), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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