Retinoblastoma-binding protein 5 (RBBP5) Recombinant Protein | RBBP5 recombinant protein

Recombinant Human Retinoblastoma-binding protein 5 (RBBP5)

Cat. Num. AAA1358453

• Gene Names: RBBP5; RBQ3; SWD1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Retinoblastoma-binding protein 5 (RBBP5); Recombinant Human Retinoblastoma-binding protein 5 (RBBP5); RBBP5 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-538, Full length protein
• Sequence: MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL
• Sequence Length: 538

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for RBBP5 recombinant protein

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B.

NCBI and Uniprot Product Information

• NCBI GI #: 300796323
• NCBI GeneID: 5929
• NCBI Accession #: NP_001180201.1
• NCBI GenBank Nucleotide #: NM_001193272.1
• UniProt Accession #: Q15291; Q7Z6D8; Q8NDZ7; A8K272
• Molecular Weight: 55,072 Da
• NCBI Official Full Name: retinoblastoma-binding protein 5 isoform 2
• NCBI Official Synonym Full Names: RB binding protein 5, histone lysine methyltransferase complex subunit
• NCBI Official Symbol: RBBP5
• NCBI Official Synonym Symbols: RBQ3; SWD1
• NCBI Protein Information: retinoblastoma-binding protein 5
• UniProt Protein Name: Retinoblastoma-binding protein 5
• Protein Family: Retinoblastoma-binding protein
• UniProt Gene Name: RBBP5
• UniProt Synonym Gene Names: RBQ3; RBBP-5

NCBI Description

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010]

Uniprot Description

In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.