Mouse retinoblastoma binding protein 4 ELISA Kit | RBBP4 elisa kit

Mouse Histone-binding protein RBBP4, RBBP4 ELISA Kit

Cat. Num. AAA9316366

• Gene Names: Rbbp4; mRbAp48
• Reactivity: Mouse
• Synonyms: retinoblastoma binding protein 4; Mouse Histone-binding protein RBBP4; RBBP4 ELISA Kit; Mouse Histone-binding protein RBBP4 (RBBP4) ELISA kit; NURF55; RBAP48; MSI1 protein homolog; chromatin assembly factor/CAF-1 p48 subunit; retinoblastoma-binding protein 4; retinoblastoma-binding protein p48; RBBP4 elisa kit

• Reactivity: Mouse
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances
• Assay Type: Sandwich
• Detection Range: 3.12ng/ml-100ng/ml
• Sensitivity: 1.0ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for RBBP4 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of RBBP4 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 47059484
• NCBI GeneID: 19646
• NCBI Accession #: NP_033056.2
• NCBI GenBank Nucleotide #: NM_009030.3
• UniProt Accession #: Q60972; A2A875
• Molecular Weight: 47,656 Da
• NCBI Official Full Name: histone-binding protein RBBP4
• NCBI Official Synonym Full Names: retinoblastoma binding protein 4
• NCBI Official Symbol: Rbbp4
• NCBI Official Synonym Symbols: mRbAp48
• NCBI Protein Information: histone-binding protein RBBP4; RBBP-4; CAF-I p48; CAF-1 subunit C; CAF-1 p48 subunit; CAF-I 48 kDa subunit; retinoblastoma-binding protein 4; retinoblastoma-binding protein p48; chromatin assembly factor 1 subunit C; chromatin assembly factor I p48 subunit; nucleosome-remodeling factor subunit RBAP48
• UniProt Protein Name: Histone-binding protein RBBP4
• Protein Family: Histone-binding protein
• UniProt Gene Name: Rbbp4
• UniProt Synonym Gene Names: Rbap48; CAF-1 subunit C; CAF-I 48 kDa subunit; CAF-I p48; RBBP-4
• UniProt Entry Name: RBBP4_MOUSE

Uniprot Description

RBBP4: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. Interacts with SUV39H1 and HDAC7. Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the chromatin assembly factor 1 (CAF-1) complex, which is composed of RBBP4, CHAF1B and CHAF1A. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Component of the PRC2/EED- EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1). Interacts with SPEN/MINT. Interacts with BRCA1. Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Cellular Component: nucleoplasm; protein complex; ESC/E(Z) complex; nuclear chromatin; NuRD complex; nucleus

Molecular Function: DNA-dependent ATPase activity; protein binding; nucleosomal DNA binding; histone deacetylase binding

Biological Process: chromatin remodeling; transcription, DNA-dependent; DNA replication-independent nucleosome assembly; regulation of transcription, DNA-dependent; ATP-dependent chromatin remodeling; chromatin assembly; chromatin modification; cell cycle; DNA replication; DNA replication-dependent nucleosome assembly