Rat retinoblastoma 1 ELISA Kit | RB1 elisa kit

Rat Retinoblastoma-associated protein, RB1 ELISA Kit

Cat. Num. AAA9334793

• Reactivity: Rat
• Synonyms: retinoblastoma 1; Rat Retinoblastoma-associated protein; RB1 ELISA Kit; Rat Retinoblastoma-associated protein (RB1) ELISA kit; OSRC; RB; p105-Rb; pRb; pp110; retinoblastoma suspectibility protein; retinoblastoma-associated protein; RB1 elisa kit

• Reactivity: Rat

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 281332095
• NCBI GeneID: 24708
• NCBI Accession #: NP_058741.1
• NCBI GenBank Nucleotide #: NM_017045.1
• UniProt Accession #: P33568; Q63527
• Molecular Weight: 105,025 Da
• NCBI Official Full Name: retinoblastoma-associated protein
• NCBI Official Synonym Full Names: retinoblastoma 1
• NCBI Official Symbol: Rb1
• NCBI Protein Information: retinoblastoma-associated protein; rb; pRb; pp105; Retinoblastoma 1 (including osteosarcoma)
• UniProt Protein Name: Retinoblastoma-associated protein
• Protein Family: Retinoblastoma-associated protein
• UniProt Gene Name: Rb1
• UniProt Synonym Gene Names: Rb-1; Rb
• UniProt Entry Name: RB_RAT

NCBI Description

plays a role in negative regulation of the cell cycle and of DNA replication; acts as a tumor suppressor [RGD, Feb 2006]

Uniprot Description

Rb: retinoblastoma tumor suppressor protein regulates cell proliferation by controlling progression through the G1-phase restriction point. Has three distinct binding domains and interacts with regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase and proteins with a conserved LXCXE motif. Cell cycle-dependent phosphorylation by Cdks inhibits Rb target binding, thus allowing cell cycle progression. Recruits and targets histone methyltransferase suv39h1 leading to epigenetic transcriptional repression.

Protein type: Transcription, coactivator/corepressor; Tumor suppressor; Oncoprotein; Nuclear receptor co-regulator

Cellular Component: transcription factor complex; PML body; Rb-E2F complex; spindle; nucleus

Molecular Function: identical protein binding; protein binding; enzyme binding; DNA binding; ubiquitin protein ligase binding; phosphoprotein binding; kinase binding; transcription factor binding

Biological Process: sister chromatid biorientation; regulation of cell cycle; regulation of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; neuron maturation; negative regulation of cell cycle; neuron differentiation; negative regulation of cell proliferation; negative regulation of mitotic cell cycle; positive regulation of macrophage differentiation; cell cycle arrest; neurite development; negative regulation of epithelial cell proliferation; transcription, DNA-dependent; enucleate erythrocyte differentiation; regulation of lipid kinase activity; chromatin modification; myoblast differentiation; regulation of transcription from RNA polymerase II promoter; neuron apoptosis; maintenance of mitotic sister chromatid cohesion; gut development; cell division; neuron morphogenesis during differentiation; negative regulation of smoothened signaling pathway; Ras protein signal transduction; positive regulation of mitotic metaphase/anaphase transition; negative regulation of protein kinase activity; striated muscle cell differentiation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; G1/S transition of mitotic cell cycle