CNG1, Rat Peptide | CNGA1 peptide
CNG1, Rat (Cyclic Nucleotide-Gated Channels 1) Control Peptide
Highly purified
Highly purified
Antibody Blocking: 5-10ug per 1ul C5999 (antiserum) or 1ug C5999-05 (affinity purified antibody).
The cyclic nucleotides cAMP and cGMP are implicated in signal transduction events such as the visual transduction, relaxation of smooth muscles, intestinal secretion of water and salt, reabsorption of Na+ and water in the distal tubule of the nephrons. cAMP/cGMP activate Ca2+ -permeable ion channels called cyclic nucleotide-gated channels (CNG or CNC). Activation of CNG leads to depolarization of the membrane voltage and to a concomitant increase of the cytosolic Ca2+. CNG consists of two distinct subunits, designated alpha and beta subunits. Several CNG a-subunits (CNG alpha 1-3) and b-subunits (subunit 2 or CNGb1-2 or CNG4-5) and numerous isoforms. a-subunit can form functional channel by themselves. b-subunits modulate the channel property of a-subunits. CNG display intracellular N and C-termini, 6 transmembrane domains or segments (S1-S6). The region between S5 and S6 contains the ion-conducting pore (P). The cyclic nucleotide-binding region is found at the c-terminus. Native functional CNG may exists as heteromultimer containing some combination of a and b subunits.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Description
Function: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Subunit structure: Tetramer formed of three CNGA1 and one CNGB1 modulatory subunits
By similarity.
Subcellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Rod cells in the retina.
Domain: The C-terminal coiled-coil domain mediates homotrimerization of CNGA subunits
By similarity.
Involvement in disease: Retinitis pigmentosa 49 (RP49) [MIM:613756]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Ref.8
Sequence similarities: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily. [View classification]Contains 1 cyclic nucleotide-binding domain.
Caution: It is uncertain whether Met-1 or Met-5 is the initiator.
Sequence caution: The sequence AAB22778.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
Research Articles on CNGA1
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Product Notes
The CNGA1 cnga1 (Catalog #AAA658757) is a Peptide produced from Rat and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CNG1, Rat can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA). Dilution: ELISA: 0.5-1ug/ml Antibody Blocking: 5-10ug per 1ul C5999 (antiserum) or 1ug C5999-05 (affinity purified antibody). Researchers should empirically determine the suitability of the CNGA1 cnga1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CNG1, Rat, Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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