Rat TFIIH basal transcription factor complex helicase XPB subunit (ERCC3) ELISA Kit | ERCC3 elisa kit
Rat TFIIH basal transcription factor complex helicase XPB subunit (ERCC3) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. [provided by RefSeq, Jul 2008]
Uniprot Description
XPB: ATP-dependent 3'-5' DNA helicase, component of the core- TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage. One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. Interacts with PUF60. Interacts with ATF7IP. Interacts with Epstein-Barr virus EBNA2. Belongs to the helicase family. RAD25/XPB subfamily.
Protein type: Transcription factor; EC 3.6.4.12; Helicase; DNA repair, damage
Chromosomal Location of Human Ortholog: 2q21
Cellular Component: nucleoplasm; holo TFIIH complex; nucleus
Molecular Function: protein C-terminus binding; DNA-dependent ATPase activity; GTP binding; ATPase activity; dATP binding; 3'-5' DNA helicase activity; protein N-terminus binding; transcription factor binding; peptide binding; protein kinase activity; RNA polymerase subunit kinase activity; ATP-dependent DNA helicase activity; protein binding; DNA binding; damaged DNA binding; ATP binding
Biological Process: transcription from RNA polymerase II promoter; DNA topological change; viral reproduction; positive regulation of apoptosis; positive regulation of viral transcription; apoptosis; protein amino acid phosphorylation; regulation of gene expression, epigenetic; protein localization; mRNA capping; UV protection; negative regulation of gene expression, epigenetic; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA damage removal; response to UV; transcription initiation from RNA polymerase II promoter; nucleotide-excision repair, DNA incision; transcription from RNA polymerase I promoter; hair cell differentiation; RNA elongation from RNA polymerase I promoter; DNA repair; termination of RNA polymerase I transcription; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; gene expression; response to oxidative stress; transcription initiation from RNA polymerase I promoter
Disease: Trichothiodystrophy 2, Photosensitive; Xeroderma Pigmentosum, Complementation Group B
Research Articles on ERCC3
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Product Notes
The Rat ERCC3 ercc3 (Catalog #AAA7251053) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7251053 ELISA Kit recognizes Rat ERCC3. It is sometimes possible for the material contained within the vial of "TFIIH basal transcription factor complex helicase XPB subunit (ERCC3), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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