Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Synaptotagmin-1 (SYT1) Standard Curve.)
Rat Synaptotagmin-1 (SYT1) ELISA Kit | SYT1 elisa kit
Rat Synaptotagmin-1 (SYT1) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Synaptotagmin-1 (SYT1) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Synaptotagmin-1 (SYT1) Standard Curve.)
Background: The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
NCBI and Uniprot Product Information
NCBI Description
integral component of synaptic vesicle membranes; important for exocytosis and vesicle trafficking to the active zone of synapses; may be the calcium sensor for calcium-dependent exocytosis [RGD, Feb 2006]
Uniprot Description
SYT1: an integral membrane protein of synaptic vesicles thought to serve as a Ca(2+) sensor in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. Binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
Protein type: Calcium-binding; Vesicle; Membrane protein, integral
Cellular Component: neuron projection; synaptic vesicle membrane; cell; integral to membrane; excitatory synapse; terminal button; intracellular organelle; secretory granule; presynaptic membrane; SNARE complex; synaptic vesicle; cytoplasm; plasma membrane; cell junction
Molecular Function: protein C-terminus binding; identical protein binding; clathrin binding; calcium-dependent phospholipid binding; transporter activity; calcium ion binding; calcium-dependent protein binding; calmodulin binding; phosphatidylinositol-4,5-bisphosphate binding; SNARE binding; protein binding; syntaxin binding; low-density lipoprotein receptor binding; phosphatidylserine binding; syntaxin-1 binding; phospholipid binding
Biological Process: positive regulation of calcium ion-dependent exocytosis; synaptic vesicle exocytosis; vesicle docking; regulation of synaptic transmission, glutamatergic; neurotransmitter secretion; positive regulation of vesicle fusion; detection of calcium ion; response to calcium ion; regulation of calcium ion-dependent exocytosis; positive regulation of synaptic transmission; calcium ion-dependent exocytosis
Research Articles on SYT1
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Product Notes
The Rat SYT1 syt1 (Catalog #AAA9711763) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9711763 ELISA Kit recognizes Rat SYT1. It is sometimes possible for the material contained within the vial of "Synaptotagmin-1 (SYT1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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