Rat Rho guanine nucleotide exchange factor 7 (Arhgef7/Pak3bp/Pixb) ELISA Kit | Arhgef7/Pak3bp/Pixb elisa kit
Rat Rho guanine nucleotide exchange factor 7, Arhgef7/Pak3bp/Pixb ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Rac/Cdc42-specific guanine nucleotide exchange factor; mediates bFGF-induced neurite outgrowth [RGD, Feb 2006]
Uniprot Description
ARHGEF7: a RAC1 guanine nucleotide exchange factor (GEF). Can induce membrane ruffling. Interacts with PAK kinases through its SH3 domain. Acts both as an activator and a downstream target for Cdc42. Its EGF-dependent phosphorylation activates its nucleotide exchange factor for Cdc42 and regulates its interaction with the E3 ligase Cbl, thus modulating Cbl-catalysed EGFR degradation. Its phosphorylation status is necessary to maintain the balance between normal signaling by EGFR and Src versus aberrant growth and transformation. Four alternatively spliced isoforms have been described.
Protein type: GEFs, Rac/Rho; Motility/polarity/chemotaxis; GEFs
Cellular Component: ruffle; neuron projection; growth cone; protein complex; focal adhesion; cell soma; lamellipodium; cytoplasm; cell cortex
Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; protein kinase binding
Biological Process: lamellipodium biogenesis; focal adhesion formation; positive regulation of apoptosis; small GTPase mediated signal transduction; hemopoietic progenitor cell differentiation; astrocyte cell migration; positive regulation of GTPase activity
Research Articles on Arhgef7/Pak3bp/Pixb
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Product Notes
The Rat Arhgef7/Pak3bp/Pixb arhgef7 (Catalog #AAA9318520) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9318520 ELISA Kit recognizes Rat Arhgef7/Pak3bp/Pixb. It is sometimes possible for the material contained within the vial of "Rho guanine nucleotide exchange factor 7 (Arhgef7/Pak3bp/Pixb), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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