Rat PTK2B protein tyrosine kinase 2 beta ELISA Kit | PTK2B elisa kit
Rat Protein-tyrosine kinase 2-beta, PTK2B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
may phosphorylate focal adhesion kinase FAK; may play a role in actin cytoskeleton reorganization; may mediate thrombin induced astrocyte proliferation [RGD, Feb 2006]
Uniprot Description
Pyk2: a nonreceptor tyrosine kinase of the Fak family. Predominantly expressed in the cells derived from hematopoietic lineages and in the central nervous system. Pyk2 is one of the signaling mediators for G-protein-coupled receptors. Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. It plays an important role in cell motility such as spreading and migration. Two alternatively spliced isoforms have been described.
Protein type: Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 2.7.10.2; TK group; Fak family
Cellular Component: focal adhesion; postsynaptic density; dendrite; cell cortex; N-methyl-D-aspartate selective glutamate receptor complex; lipid raft; nucleoplasm; extrinsic to internal side of plasma membrane; cytoskeleton; growth cone; cell soma; axon; lamellipodium; perinuclear region of cytoplasm; cytoplasm; nucleus
Molecular Function: protein binding; calmodulin-dependent protein kinase activity; 3-phosphoinositide-dependent protein kinase binding; N-methyl-D-aspartate selective glutamate receptor activity; protein complex binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; protein kinase activity; receptor binding
Biological Process: focal adhesion formation; positive regulation of JNK activity; regulation of nitric oxide biosynthetic process; regulation of cGMP biosynthetic process; protein amino acid phosphorylation; glial cell proliferation; regulation of cell shape; regulation of inositol trisphosphate biosynthetic process; negative regulation of bone mineralization; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; negative regulation of ossification; response to glucose stimulus; negative regulation of neuron apoptosis; cell adhesion; neurite development; bone resorption; response to drug; negative regulation of myeloid cell differentiation; positive regulation of nitric-oxide synthase activity; actin filament organization; response to osmotic stress; response to organic nitrogen; positive regulation of cell growth; marginal zone B cell differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of angiogenesis; response to reactive oxygen species; response to ethanol; response to mechanical stimulus; ionotropic glutamate receptor signaling pathway; response to calcium ion; negative regulation of apoptosis; activation of JAK protein; response to cAMP; peptidyl-tyrosine phosphorylation; blood vessel endothelial cell migration; positive regulation of translation; negative regulation of potassium ion transport; response to lithium ion; response to hormone stimulus; positive regulation of JNK cascade; regulation of calcium-mediated signaling; positive regulation of synaptic transmission, glutamatergic; negative regulation of cell proliferation; positive regulation of cell proliferation; angiogenesis; cell differentiation; positive regulation of cell-matrix adhesion; integrin-mediated signaling pathway; epidermal growth factor receptor signaling pathway; regulation of cell adhesion; MAPKKK cascade; signal complex assembly; positive regulation of phosphoinositide 3-kinase activity; response to cocaine; oocyte maturation; regulation of release of sequestered calcium ion into cytosol; positive regulation of actin filament polymerization; response to hydrogen peroxide; positive regulation of protein kinase activity; stress fiber formation; response to hypoxia; innate immune response; cellular defense response; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; positive regulation of cell migration
Research Articles on PTK2B
Similar Products
Product Notes
The Rat PTK2B ptk2b (Catalog #AAA9332016) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332016 ELISA Kit recognizes Rat PTK2B. It is sometimes possible for the material contained within the vial of "PTK2B protein tyrosine kinase 2 beta, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
