Rat Methylenetetrahydrofolate Reductase ELISA Kit | Mthfr elisa kit

Rat Methylenetetrahydrofolate Reductase ELISA Kit

Cat. Num. AAA3809274

• Gene Names: Mthfr; AI323986
• Reactivity: Rat
• Synonyms: Methylenetetrahydrofolate Reductase; Rat Methylenetetrahydrofolate Reductase ELISA Kit; Mthfr elisa kit

• Reactivity: Rat
• Sequence Length: 654

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 2.5 U/L-40 U/L
• Sensitivity: 0.1 U/L

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for Mthfr elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofRat methylenetetrahydrofolate reductase in the sample, This Rat methylenetetrahydrofolate reductase Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusRat methylenetetrahydrofolate reductase concentration. The concentration ofRat methylenetetrahydrofolate reductase in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 31543271
• NCBI GeneID: 17769
• NCBI Accession #: NP_034970.2
• NCBI GenBank Nucleotide #: NP_034970.2
• UniProt Accession #: Q9WU20
• NCBI Official Full Name: methylenetetrahydrofolate reductase isoform b
• NCBI Official Synonym Full Names: methylenetetrahydrofolate reductase
• NCBI Official Symbol: Mthfr
• NCBI Official Synonym Symbols: AI323986
• NCBI Protein Information: methylenetetrahydrofolate reductase
• UniProt Protein Name: Methylenetetrahydrofolate reductase
• Protein Family: Methylenetetrahydrofolate reductase
• UniProt Gene Name: Mthfr
• UniProt Entry Name: MTHR_MOUSE

Uniprot Description

MTHFR: Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine. Defects in MTHFR are the cause of methylenetetrahydrofolate reductase deficiency (MTHFRD). MTHFRD is autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia, developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders. Defects in MTHFR may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in MTHFR may be a cause of susceptibility to folate-sensitive neural tube defects (FS-NTD). The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Belongs to the methylenetetrahydrofolate reductase family.

Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; Energy Metabolism - methane; EC 1.5.1.20; Oxidoreductase

Cellular Component: neuron projection; cytosol

Molecular Function: FAD binding; oxidoreductase activity; NADP binding; methylenetetrahydrofolate reductase (NADPH) activity; catalytic activity

Biological Process: tetrahydrofolate metabolic process; metabolic process; methionine biosynthetic process; methionine metabolic process; homocysteine metabolic process; one-carbon compound metabolic process