Rat Leptin Receptor (LEPR) ELISA Kit | LEPR elisa kit

Rat Leptin Receptor (LEPR) ELISA Kit

Cat. Num. AAA453152

• Gene Names: Lepr; Fa
• Reactivity: Rat
• Synonyms: Leptin Receptor (LEPR); Rat Leptin Receptor (LEPR) ELISA Kit; CD295; LEPR; OBR; LR; LEPR elisa kit

• Reactivity: Rat
• Sequence Length: 1162

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 1.56-100ng/mL
• Sensitivity: 0.66ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 6981150
• NCBI GeneID: 24536
• NCBI Accession #: NP_036728.1
• NCBI GenBank Nucleotide #: NM_012596.1
• UniProt Accession #: Q62959; O35772; O35773; O54805; P70493; P70494; P70495; P97589; Q62960; Q63007; Q63385; Q63386
• Molecular Weight: 101,395 Da
• NCBI Official Full Name: leptin receptor
• NCBI Official Synonym Full Names: leptin receptor
• NCBI Official Symbol: Lepr
• NCBI Official Synonym Symbols: Fa
• NCBI Protein Information: leptin receptor
• UniProt Protein Name: Leptin receptor
• Protein Family: Leptin receptor
• UniProt Gene Name: Lepr
• UniProt Synonym Gene Names: Fa; Obr; LEP-R; OB-R

NCBI Description

receptor for leptin; may have a role in body weight maintainence [RGD, Feb 2006]

Uniprot Description

Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:8690163). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production ().