Rat Indoleamine-2,3-Dioxygenase (IDO) ELISA Kit | IDO elisa kit

Rat Indoleamine-2,3-Dioxygenase (IDO) ELISA Kit

Cat. Num. AAA452303

• Gene Names: Ido1; Ido; Indo
• Reactivity: Rat
• Synonyms: Indoleamine-2; 3-Dioxygenase (IDO); Rat Indoleamine-2; 3-Dioxygenase (IDO) ELISA Kit; CD107B; INDO; Indoleamine-Pyrrole 2; 3 Dioxygenase; IDO elisa kit

• Reactivity: Rat
• Sequence Length: 407

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.156-10ng/mL
• Sensitivity: 0.053ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 13027384
• NCBI GeneID: 66029
• NCBI Accession #: NP_076463.1
• NCBI GenBank Nucleotide #: NM_023973.1
• UniProt Accession #: Q9ERD9
• Molecular Weight: 45,831 Da
• NCBI Official Full Name: indoleamine 2,3-dioxygenase 1
• NCBI Official Synonym Full Names: indoleamine 2,3-dioxygenase 1
• NCBI Official Symbol: Ido1
• NCBI Official Synonym Symbols: Ido; Indo
• NCBI Protein Information: indoleamine 2,3-dioxygenase 1
• UniProt Protein Name: Indoleamine 2,3-dioxygenase 1
• Protein Family: L-isoleucine-4-hydroxylase
• UniProt Gene Name: Ido1
• UniProt Synonym Gene Names: Ido; Indo; IDO-1

NCBI Description

enzyme which catalyzes degradation of L-tryptophan to N-formylkynurenine; human homolog is induced by gamma-interferon and is believed to be involved in that agent's tumor antiproliferative effects [RGD, Feb 2006]

Uniprot Description

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection.