Rat Csrp3/Cysteine and glycine-rich protein 3 ELISA Kit | Csrp3 elisa kit

Rat Csrp3/Cysteine and glycine-rich protein 3 ELISA Kit

Cat. Num. AAA2904500

• Gene Names: Csrp3; MLP
• Reactivity: Rat
• Synonyms: Csrp3/Cysteine and glycine-rich protein 3; Rat Csrp3/Cysteine and glycine-rich protein 3 ELISA Kit; Cysteine-rich protein 3; CRP3; LIM domain protein; cardiac; Muscle LIM protein; Clp; Mlp; Cysteine and glycine-rich protein 3; Csrp3 elisa kit

• Reactivity: Rat
• Specificity: Natural and recombinant Rat Cysteine and glycine-rich protein 3

• Assay Type: Sandwich
• Detection Range: 0.156-10ng/mL
• Sensitivity: 0.063ng/mL
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 16924004
• NCBI GeneID: 117505
• NCBI Accession #: NP_476485.1
• NCBI GenBank Nucleotide #: NM_057144.1
• UniProt Accession #: P50463
• Molecular Weight: 20,803 Da
• NCBI Official Full Name: cysteine and glycine-rich protein 3
• NCBI Official Synonym Full Names: cysteine and glycine-rich protein 3 (cardiac LIM protein)
• NCBI Official Symbol: Csrp3
• NCBI Official Synonym Symbols: MLP
• NCBI Protein Information: cysteine and glycine-rich protein 3; CRP3; muscle LIM protein; cysteine-rich protein 3; LIM domain protein, cardiac
• UniProt Protein Name: Cysteine and glycine-rich protein 3
• Protein Family: Cysteine and glycine-rich protein
• UniProt Gene Name: Csrp3
• UniProt Synonym Gene Names: Clp; Mlp; CRP3
• UniProt Entry Name: CSRP3_RAT

NCBI Description

may play a role in positive regulation of myogenesis [RGD, Feb 2006]

Uniprot Description

CSRP3: Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. Defects in CSRP3 are the cause of cardiomyopathy dilated type 1M (CMD1M). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in CSRP3 are the cause of familial hypertrophic cardiomyopathy type 12 (CMH12). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Protein type: Transcription regulation

Cellular Component: cytoskeleton; cell; cytoplasm; nucleus; Z disc

Molecular Function: actinin binding; MRF binding; telethonin binding; zinc ion binding; structural constituent of muscle

Biological Process: cellular calcium ion homeostasis; cardiac muscle development; muscle development; protein localization in organelle; cardiac myofibril assembly; blood vessel remodeling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; cell differentiation; regulation of the force of heart contraction; cardiac muscle contraction