Rat cardiac myosin heavy chain, MHC autoantibody ELISA Kit | MHC elisa kit

Rat cardiac myosin heavy chain, MHC autoantibody ELISA Kit

Cat. Num. AAA2605019

• Gene Names: MYH7; CMH1; MPD1; SPMD; SPMM; CMD1S; MYHCB
• Reactivity: Rat
• Synonyms: cardiac myosin heavy chain; MHC autoantibody; Rat cardiac myosin heavy chain; MHC autoantibody ELISA Kit; MHC elisa kit

• Reactivity: Rat
• Sequence Length: 1934

• Preparation and Storage: Store all reagents at 2-8 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 29727
• NCBI GeneID: 4625
• UniProt Accession #: P12883; Q14836; Q14837; Q14904; Q16579; Q2M1Y6; Q92679; Q9H1D5; Q9UDA2; Q9UMM8; A2TDB6; B6D424
• Molecular Weight: 223,097 Da
• NCBI Official Full Name: cardiac beta myosin heavy chain
• NCBI Official Synonym Full Names: myosin, heavy chain 7, cardiac muscle, beta
• NCBI Official Symbol: MYH7
• NCBI Official Synonym Symbols: CMH1; MPD1; SPMD; SPMM; CMD1S; MYHCB
• NCBI Protein Information: myosin-7
• UniProt Protein Name: Myosin-7
• Protein Family: Myosin
• UniProt Gene Name: MYH7
• UniProt Synonym Gene Names: MYHCB; MyHC-slow; MyHC-beta
• UniProt Entry Name: MYH7_HUMAN

NCBI Description

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008]

Uniprot Description

MYH7: Muscle contraction. Defects in MYH7 are the cause of familial hypertrophic cardiomyopathy type 1 (CMH1). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in MYH7 are the cause of myopathy myosin storage (MYOMS). In this disorder, muscle biopsy shows type 1 fiber predominance and increased interstitial fat and connective tissue. Inclusion bodies consisting of the beta cardiac myosin heavy chain are present in the majority of type 1 fibers, but not in type 2 fibers. Defects in MYH7 are the cause of scapuloperoneal myopathy MYH7-related (SPMM); also known as scapuloperoneal syndrome myopathic type. SPMM is a progressive muscular atrophia beginning in the lower legs and affecting the shoulder region earlier and more severely than distal arm. Defects in MYH7 are a cause of cardiomyopathy dilated type 1S (CMD1S). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in MYH7 are the cause of myopathy distal type 1 (MPD1). MPD1 is a muscular disorder characterized by early-onset selective weakness of the great toe and ankle dorsiflexors, followed by weakness of the finger extensors. Mild proximal weakness occasionally develops years later after the onset of the disease.

Protein type: Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: muscle myosin complex; myosin complex; sarcomere; stress fiber; Z disc

Molecular Function: actin binding; actin-dependent ATPase activity; ATP binding; ATPase activity; calmodulin binding; microfilament motor activity; protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: adult heart development; ATP metabolic process; cardiac muscle contraction; muscle contraction; muscle filament sliding; regulation of heart rate; regulation of slow-twitch skeletal muscle contraction; regulation of the force of heart contraction; regulation of the force of skeletal muscle contraction; skeletal muscle contraction; striated muscle contraction; transition between fast and slow fiber; ventricular cardiac muscle morphogenesis

Disease: Cardiomyopathy, Dilated, 1s; Cardiomyopathy, Familial Hypertrophic, 1; Myopathy, Congenital, With Fiber-type Disproportion; Myopathy, Distal, 1; Myopathy, Myosin Storage; Myopathy, Myosin Storage, Autosomal Recessive; Scapuloperoneal Myopathy, Myh7-related