Rat Bile Salt-Activated Lipase (BSAL) ELISA Kit | BSAL elisa kit

Rat Bile Salt-Activated Lipase (BSAL) ELISA Kit

Cat. Num. AAA9381473

• Gene Names: CEL; BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8
• Reactivity: Rat
• Synonyms: Bile Salt-Activated Lipase (BSAL); Rat Bile Salt-Activated Lipase (BSAL) ELISA Kit; BSAL elisa kit

• Reactivity: Rat
• Sequence Length: 756

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 148536848
• NCBI GeneID: 1056
• NCBI Accession #: NP_001798.2
• NCBI GenBank Nucleotide #: NM_001807.4
• Molecular Weight: 71,834 Da
• NCBI Official Full Name: bile salt-activated lipase
• NCBI Official Synonym Full Names: carboxyl ester lipase
• NCBI Official Symbol: CEL
• NCBI Official Synonym Symbols: BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8
• NCBI Protein Information: bile salt-activated lipase
• UniProt Protein Name: Bile salt-activated lipase
• UniProt Gene Name: CEL
• UniProt Synonym Gene Names: BAL; BAL; BSSL
• UniProt Entry Name: CEL_HUMAN

NCBI Description

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]

Uniprot Description

CEL: Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides. Defects in CEL are a cause of maturity-onset diabetes of the young type 8 with exocrine dysfunction (MODY8); also known as diabetes and pancreatic exocrine dysfunction (DPED). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.13; EC 3.1.1.3; Lipase; Lipid Metabolism - glycerolipid; Lipid Metabolism - steroid biosynthesis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cell surface; cytoplasm; extracellular region; extracellular space; integral to plasma membrane; synapse

Molecular Function: acylglycerol lipase activity; catalytic activity; hydrolase activity; neurexin binding; protein binding; receptor activity; sterol esterase activity

Biological Process: cholesterol catabolic process; lipid digestion; neuron adhesion; pancreatic juice secretion; regulation of synaptic transmission; synaptogenesis; triacylglycerol metabolic process

Disease: Maturity-onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction