Rat Bcl-2-associated transcription factor 1 (BCLAF1) ELISA Kit | BCLAF1 elisa kit
Rat Bcl-2-associated transcription factor 1 (BCLAF1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
BCLAF1: a ubiquitous death-promoting transcriptional repressor. Interacts with Bcl-2 related proteins, lamin A, emerin, the adenovirus E1B 19 kDa protein and DNA. An emerin mutant S54F, which binds normally to barrier-to-autointegration factor (BAF), lamin A and GCL, selectively disrupts its binding to BCLAF1. BCLAF1 is found in dot-like structures throughout the nuclear interior in HeLa cells. Proapoptotic stimuli induce its redistribution to a distinct zone near the nuclear envelope. Four alternatively spliced human isoforms have been described.
Protein type: Transcription factor; RNA-binding
Chromosomal Location of Human Ortholog: 6q23.3
Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding
Biological Process: regulation of transcription in response to stress; transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; negative regulation of transcription, DNA-dependent
Research Articles on BCLAF1
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Product Notes
The Rat BCLAF1 bclaf1 (Catalog #AAA7225733) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7225733 ELISA Kit recognizes Rat BCLAF1. It is sometimes possible for the material contained within the vial of "Bcl-2-associated transcription factor 1 (BCLAF1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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