Rat A Disintegrin And Metalloprotease 10 (ADAM10) ELISA Kit | ADAM10 elisa kit

Rat A Disintegrin And Metalloprotease 10 (ADAM10) ELISA Kit

Cat. Num. AAA453259

• Gene Names: Adam10; MADM
• Reactivity: Rat
• Synonyms: A Disintegrin And Metalloprotease 10 (ADAM10); Rat A Disintegrin And Metalloprotease 10 (ADAM10) ELISA Kit; CD156-C; CD156c; MADM; Kuz; CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; ADAM10 elisa kit

• Reactivity: Rat
• Sequence Length: 544

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 78.125-5000pg/mL
• Sensitivity: 27pg/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 37096570
• NCBI GeneID: 29650
• UniProt Accession #: Q10743
• Molecular Weight: 60,445 Da
• NCBI Official Full Name: Disintegrin and metalloproteinase domain-containing protein 10
• NCBI Official Synonym Full Names: ADAM metallopeptidase domain 10
• NCBI Official Symbol: Adam10
• NCBI Official Synonym Symbols: MADM
• NCBI Protein Information: disintegrin and metalloproteinase domain-containing protein 10
• UniProt Protein Name: Disintegrin and metalloproteinase domain-containing protein 10
• Protein Family: Disintegrin and metalloproteinase domain-containing protein
• UniProt Gene Name: Adam10
• UniProt Synonym Gene Names: Madm; ADAM 10

NCBI Description

may act as a disintegrin-metalloprotease related to the reprolysin family [RGD, Feb 2006]

Uniprot Description

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.