Human Ras protein-specific guanine nucleotide-releasing factor 2 ELISA Kit | RASGRF2 elisa kit
Human Ras-specific guanine nucleotide-releasing factor 2, RASGRF2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]
Uniprot Description
RASGRF2: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.
Protein type: GEFs; GEFs, Ras
Chromosomal Location of Human Ortholog: 5q13
Cellular Component: endoplasmic reticulum membrane; plasma membrane; cytosol
Molecular Function: calmodulin binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: synaptic transmission; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction
Research Articles on RASGRF2
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Product Notes
The Human RASGRF2 rasgrf2 (Catalog #AAA9333238) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9333238 ELISA Kit recognizes Human RASGRF2. It is sometimes possible for the material contained within the vial of "Ras protein-specific guanine nucleotide-releasing factor 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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