Human RAS p21 protein activator 4 ELISA Kit | RASA4 elisa kit
Human Ras GTPase-activating protein 4, RASA4 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
RASA4: Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; GAPs, Ras
Chromosomal Location of Human Ortholog: 7q22
Cellular Component: cytoplasm; plasma membrane; cytosol
Molecular Function: metal ion binding; GTPase activator activity
Biological Process: negative regulation of Ras protein signal transduction
Research Articles on RASA4
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Product Notes
The Human RASA4 rasa4 (Catalog #AAA9316854) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9316854 ELISA Kit recognizes Human RASA4. It is sometimes possible for the material contained within the vial of "RAS p21 protein activator 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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