Rat Rap guanine nucleotide exchange factor (GEF) 4 ELISA Kit | RAPGEF4 elisa kit
Rat Rap guanine nucleotide exchange factor 4, RAPGEF4 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
bind cAMP and activate the guanine nucleotide binding protein Rap1A [RGD, Feb 2006]
Uniprot Description
RAPGEF4: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2. Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. 3 isoforms of the human protein are produced by alternative promoter.
Protein type: GEFs, Ras; GEFs
Cellular Component: photoreceptor inner segment; protein complex; photoreceptor outer segment; basolateral plasma membrane; axon; apical plasma membrane; cytoplasm; dendrite; plasma membrane; dendritic spine; excitatory synapse; cytosol; cAMP-dependent protein kinase complex
Molecular Function: protein binding; Ras GTPase binding; guanyl-nucleotide exchange factor activity; protein complex binding; cAMP-dependent protein kinase regulator activity; cAMP binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: exocytosis; heart development; regulation of dendrite development; signal transduction; positive regulation of smooth muscle cell migration; negative regulation of synaptic transmission; calcium ion-dependent exocytosis; regulation of exocytosis; cAMP-mediated signaling; insulin secretion; small GTPase mediated signal transduction; regulation of protein kinase activity; positive regulation of GTPase activity
Research Articles on RAPGEF4
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Product Notes
The Rat RAPGEF4 rapgef4 (Catalog #AAA9325349) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325349 ELISA Kit recognizes Rat RAPGEF4. It is sometimes possible for the material contained within the vial of "Rap guanine nucleotide exchange factor (GEF) 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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