Rabbit Rap Guanine Nucleotide Exchange Factor 1 ELISA Kit | RAPGEF1 elisa kit

Rabbit Rap Guanine Nucleotide Exchange Factor 1 ELISA Kit

Cat. Num. AAA726378

• Gene Names: RAPGEF1; C3G; GRF2
• Reactivity: Rabbit
• Synonyms: Rap Guanine Nucleotide Exchange Factor 1; Rabbit Rap Guanine Nucleotide Exchange Factor 1 ELISA Kit; RAPGEF1 elisa kit

• Reactivity: Rabbit

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 38373677
• NCBI GeneID: 2889
• NCBI Accession #: NP_941372.1
• NCBI GenBank Nucleotide #: NM_198679.1
• Molecular Weight: 122,735 Da
• NCBI Official Full Name: rap guanine nucleotide exchange factor 1 isoform b
• NCBI Official Synonym Full Names: Rap guanine nucleotide exchange factor (GEF) 1
• NCBI Official Symbol: RAPGEF1
• NCBI Official Synonym Symbols: C3G; GRF2
• NCBI Protein Information: rap guanine nucleotide exchange factor 1; CRK SH3-binding GNRP; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)
• UniProt Protein Name: Rap guanine nucleotide exchange factor 1
• Protein Family: Rap guanine nucleotide exchange factor
• UniProt Gene Name: RAPGEF1
• UniProt Synonym Gene Names: GRF2
• UniProt Entry Name: RPGF1_HUMAN

NCBI Description

This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

RAPGEF1: an adaptor-type Src homology (SH)2-containing molecule. A guanine nucleotide releasing protein for Ras. Expressed ubiquitously in human adult and fetal tissues. Several alternatively spliced transcript variants have been described.

Protein type: Motility/polarity/chemotaxis; GEFs, Ras; GEFs

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: early endosome; cytosol; endosome

Molecular Function: protein binding; Rap guanyl-nucleotide exchange factor activity; SH3 domain binding

Biological Process: blood vessel development; cell-cell adhesion; negative regulation of protein kinase B signaling cascade; activation of MAPKK activity; nerve growth factor receptor signaling pathway; negative regulation of Ras protein signal transduction; platelet-derived growth factor receptor signaling pathway; signal transduction; Rap protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway