Ran guanine nucleotide release factor (RANGRF) Recombinant Protein | RANGRF recombinant protein

Recombinant Human Ran guanine nucleotide release factor (RANGRF)

Cat. Num. AAA1286549

• Gene Names: RANGRF; MOG1; HSPC165; HSPC236; RANGNRF
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ran guanine nucleotide release factor (RANGRF); Recombinant Human Ran guanine nucleotide release factor (RANGRF); RANGRF recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-186, Full length protein
• Sequence: MEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSLENLALRGRCQEAWVLSGKQQIAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSPAPWSLGDFEQLVTSLTLHDPNIFGPQ
• Sequence Length: 186

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 295317377
• NCBI GeneID: 29098
• NCBI Accession #: NP_001171272.1
• NCBI GenBank Nucleotide #: NM_001177801.1
• UniProt Accession #: Q9HD47; Q68DI3; Q9BR68; Q9HD48; Q9NRU9; Q9P001; Q9P0P2; D3DTR6
• Molecular Weight: 12,900 Da
• NCBI Official Full Name: ran guanine nucleotide release factor isoform B
• NCBI Official Synonym Full Names: RAN guanine nucleotide release factor
• NCBI Official Symbol: RANGRF
• NCBI Official Synonym Symbols: MOG1; HSPC165; HSPC236; RANGNRF
• NCBI Protein Information: ran guanine nucleotide release factor
• UniProt Protein Name: Ran guanine nucleotide release factor
• Protein Family: Ran guanine nucleotide release factor
• UniProt Gene Name: RANGRF
• UniProt Synonym Gene Names: MOG1; RANGNRF; RanGNRF

NCBI Description

This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Uniprot Description

May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375).