Mouse RAN binding protein 2 ELISA Kit | RANBP2 elisa kit
Mouse E3 SUMO-protein ligase RanBP2, RANBP2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
RANBP2: a very large RAN-binding nucleoporin with E3 SUMO-protein ligase activity. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Forms a complex with SUMOylated RanGAP1 (the GTPase activating protein for Ran) that is required for efficient importin alpha/beta dependent nuclear import. May bind RNA or DNA. Component of the nuclear export pathway. Has a specific docking site for the nuclear export factor exportin-1. Contains a cyclophilin type peptidyl-prolyl cis-trans isomerase domain. A giant scaffolding protein that forms filaments extending from the nuclear pore into the cytoplasm. Regulates the localization of mitochondria in photosensory neurons. Deficits of RanBP2 downregulate glucose catabolism and energy homeostasis. Forms a tight complex with RANBP1 and UBE2I. Interacts with SUMO1 and PARK2. For some substrates, sumoylation and nuclear import are linked events. Sumoylates proteins including SP100 and HDAC4 deacetylase.
Protein type: EC 6.3.2.-; Nucleoporin; EC 5.2.1.8; Adaptor/scaffold; SUMO conjugating system; Ligase; Nuclear export
Cellular Component: membrane; mitochondrion; nuclear pore; nucleus
Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; RNA binding; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; metal ion binding; ribosomal S6-glutamic acid ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; ligase activity
Biological Process: negative regulation of glucokinase activity; protein transport; mRNA transport; intracellular transport; protein peptidyl-prolyl isomerization; protein folding; transport
Research Articles on RANBP2
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Product Notes
The Mouse RANBP2 ranbp2 (Catalog #AAA9341315) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9341315 ELISA Kit recognizes Mouse RANBP2. It is sometimes possible for the material contained within the vial of "RAN binding protein 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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