Rabbit Potassium channel subfamily K member 1, KCNK1 ELISA Kit | KCNK1 elisa kit

Rabbit Potassium channel subfamily K member 1, KCNK1 ELISA Kit

Cat. Num. AAA1601466

• Gene Names: KCNK1; DPK; HOHO; K2P1; KCNO1; TWIK1; K2p1.1; TWIK-1
• Reactivity: Rabbit
• Synonyms: Potassium channel subfamily K member 1; KCNK1; Rabbit Potassium channel subfamily K member 1; KCNK1 ELISA Kit; KCNK1 elisa kit

• Reactivity: Rabbit
• Sequence Length: 336

• Preparation and Storage: Store at 2 to 8 degree C for 6 months.

NCBI and Uniprot Product Information

• NCBI GI #: 4504847
• NCBI GeneID: 3775
• NCBI Accession #: NP_002236.1
• NCBI GenBank Nucleotide #: NM_002245.3
• UniProt Accession #: O00180; Q13307; Q5T5E8
• Molecular Weight: 38,143 Da
• NCBI Official Full Name: potassium channel subfamily K member 1
• NCBI Official Synonym Full Names: potassium two pore domain channel subfamily K member 1
• NCBI Official Symbol: KCNK1
• NCBI Official Synonym Symbols: DPK; HOHO; K2P1; KCNO1; TWIK1; K2p1.1; TWIK-1
• NCBI Protein Information: potassium channel subfamily K member 1
• UniProt Protein Name: Potassium channel subfamily K member 1
• Protein Family: Potassium channel subfamily
• UniProt Gene Name: KCNK1
• UniProt Synonym Gene Names: HOHO11 PublicationManual assertion based on opinion iniRef.2

NCBI Description

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

Uniprot Description

Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K+ ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na+ at subphysiological K+ levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086). Channel activity is modulated by activation of serotonin receptors (). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (). Required for normal ion and water transport in the kidney (). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478).