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Rabbit Atrophin-1 (ATN1) ELISA Kit | ATN1 elisa kit

Rabbit Atrophin-1 (ATN1) ELISA Kit

Gene Names
ATN1; B37; HRS; NOD; DRPLA; D12S755E
Reactivity
Rabbit
Synonyms
Atrophin-1 (ATN1); Rabbit Atrophin-1 (ATN1) ELISA Kit; ATN1 elisa kit
Ordering
 
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For Research Use Only!
Reactivity
Rabbit
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
Preparation and Storage
Store all reagents at 2-8 degree C.
Product Categories/Family for ATN1 elisa kit

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
125,414 Da
NCBI Official Full Name
atrophin-1
NCBI Official Synonym Full Names
atrophin 1
NCBI Official Symbol
ATN1
NCBI Official Synonym Symbols
B37; HRS; NOD; DRPLA; D12S755E
NCBI Protein Information
atrophin-1; dentatorubral-pallidoluysian atrophy protein
UniProt Protein Name
Atrophin-1
Protein Family
UniProt Gene Name
ATN1
UniProt Synonym Gene Names
D12S755E; DRPLA
UniProt Entry Name
ATN1_HUMAN

NCBI Description

Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-23 copies to 49-75 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Feb 2010]

Uniprot Description

DRPLA: a protein that interacts with the E3 ubiquitin-protein ligase WWP1 and WWP2. May be involved in the third step of ubiquitin conjugation. Relatively high levels in the brain, ovary, testis and prostate. Lower levels in the liver, thymus and leukocytes. Defects are the cause of the neurodegenerative disorders dentatorubral-pallidoluysian atrophy (DRPLA) and Haw River syndrome (HRS).

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: nucleoplasm; nuclear matrix; perinuclear region of cytoplasm; cytoplasm; nucleus; cell junction

Molecular Function: protein domain specific binding; protein binding; toxin receptor binding; transcription corepressor activity

Biological Process: neuron apoptosis; cell migration; central nervous system development; transcription, DNA-dependent; toxin metabolic process; negative regulation of transcription from RNA polymerase II promoter; maintenance of cell polarity

Disease: Dentatorubral-pallidoluysian Atrophy

Research Articles on ATN1

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Product Notes

The Rabbit ATN1 atn1 (Catalog #AAA7207394) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7207394 ELISA Kit recognizes Rabbit ATN1. It is sometimes possible for the material contained within the vial of "Atrophin-1 (ATN1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.
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