Rabbit AP-2 complex subunit alpha-1 (AP2A1) ELISA Kit | AP2A1 elisa kit
Rabbit AP-2 complex subunit alpha-1 (AP2A1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
AP2A1: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C- terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. Belongs to the adaptor complexes large subunit family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: clathrin coat of trans-Golgi network vesicle; membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane; AP-2 adaptor complex; cytosol
Molecular Function: protein C-terminus binding; protein binding; protein kinase binding; protein transporter activity
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; synaptic transmission; axon guidance; intracellular protein transport; nerve growth factor receptor signaling pathway; viral reproduction; Golgi to endosome transport; ephrin receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class II; endocytosis; regulation of defense response to virus by virus
Research Articles on AP2A1
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Product Notes
The Rabbit AP2A1 ap2a1 (Catalog #AAA7234768) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7234768 ELISA Kit recognizes Rabbit AP2A1. It is sometimes possible for the material contained within the vial of "AP-2 complex subunit alpha-1 (AP2A1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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