Rabbit Apolipoprotein CII Antibody | anti-Apo CII antibody

Rabbit Anti-Human Apolipoprotein CII Affinity Pure

Cat. Num. AAA390057

• Gene Names: APOC2; APO-CII; APOC-II
• Applications: ELISA, Immunoblot, Western Blot
• Synonyms: Apolipoprotein CII; Rabbit Anti-Human Apolipoprotein CII Affinity Pure; Rabbit Anti-Human Apolipoprotein CII (Apo CII); Polyclonal Antibody; Affinity Purified; anti-Apo CII antibody

• Host: Rabbit
• Specificity: Specifically binds to human apo CII. Dilution for immunoblot and ELISA range: 200 to 8,000.
• Concentration: 1.0 mg / ml (OD 1.35 /280 nm). (varies by lot)
• Sequence Length: 84

• Applicable Applications for anti-Apo CII antibody: ELISA (EIA), Immunoblot (IB)
• Application Notes: Dilution for Immunoblot & ELISA range: 1,000 to 8,000.; Use: The antibody can be used for detection of apo CII in plasma and lipoproteins, immunoassays, immunoblots, enzyme conjugation, or biotinylation.
• Source Note: Rabbit anti-human apo CII polyclonal antibody purified by human apo CII-Sepharose affinity column.
• Buffer: 75 mM PBS, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2.
• Preparation and Storage: -20 degree C for long-term storage, 2-8 degree C for short-term storage. Aliquot to avoid repeated freezing and thawing.

Testing Data)

Product Categories/Family for anti-Apo CII antibody

Aff. Pure AB

NCBI and Uniprot Product Information

• NCBI GI #: 178825
• NCBI GeneID: 344
• UniProt Accession #: P02655; Q9BS39; Q9UDE3; Q9UNK3; C0JYY4
• Molecular Weight: 11,284 Da
• NCBI Official Full Name: apolipoprotein CII
• NCBI Official Synonym Full Names: apolipoprotein C-II
• NCBI Official Symbol: APOC2
• NCBI Official Synonym Symbols: APO-CII; APOC-II
• NCBI Protein Information: apolipoprotein C-II; apolipoprotein C2
• UniProt Protein Name: Apolipoprotein C-II
• UniProt Gene Name: APOC2
• UniProt Synonym Gene Names: APC2; Apo-CII; ApoC-II
• UniProt Entry Name: APOC2_HUMAN

NCBI Description

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

Uniprot Description

Function: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.

Subcellular location: Secreted.

Tissue specificity: Secreted in plasma.

Involvement in disease: Hyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23

Sequence similarities: Belongs to the apolipoprotein C2 family.