RAB32 recombinant protein

Recombinant Human RAB32, Member RAS Oncogene Family

Cat. Num. AAA145031

• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: RAB32; Recombinant Human RAB32; Member RAS Oncogene Family; RAB32 Human; Member RAS Oncogene Family Human Recombinant; RAB32 member RAS oncogene family; ras-related protein Rab-32; RAB32 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: The RAB32 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 5mM DTT, 0.2M NaCl, 0.2M EDTA and 50% glycerol.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMAGGGA GDPGLGAAAA PAPETREHLF KVLVIGELGV GKTSIIKRYV HQLFSQHYRA TIGVDFALKV LNWDSRTLVR LQLWDIAGQE RFGNMTRVYY KEAVGAFVVF DISRSSTFEA VLKWKSDLDS KVHLPNGSPI PAVLLANKCD QNKDSSQSPS QVDQFCKEHG FAGWFETSAK DNINIEEAAR FLVEKILVNH QSFPNEENDV DKIKLDQETL RAENKSQCC
• Sequence Length: 225

Related Product Information for RAB32 recombinant protein

Description: RAB32 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 249 amino acids (1-225) and having a molecular mass of 27.6 kDa.RAB32 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: RAB32 is a member of the small GTPase superfamily. RAB32 controls ER calcium management and disturbs the specific enhancement of calnexin on the MAM (mitochondria-associated membrane), however avoids affecting the ER distribution of protein-disulfide isomerase and mitofusin-2. Furthermore, RAB32 regulates the targeting of PKA (cAMP-dependent protein kinase) to mitochondrial and ER membranes and by inactivation or overexpression enhances the phosphorylation of Drp1 and Bad. Using a combination of its functions as a regulator of MAM properties and a PKA-anchoring protein, the activity and expression level of RAB32 define the speed of apoptosis onset.

Product Categories/Family for RAB32 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Member RAS Oncogene Family

NCBI and Uniprot Product Information

• NCBI GI #: 5803133
• NCBI GeneID: 10981
• NCBI Accession #: NP_006825.1
• NCBI GenBank Nucleotide #: NM_006834.3
• UniProt Accession #: Q13637
• Molecular Weight: 24,997 Da
• NCBI Official Full Name: ras-related protein Rab-32
• NCBI Official Synonym Full Names: RAB32, member RAS oncogene family
• NCBI Official Symbol: RAB32
• NCBI Protein Information: ras-related protein Rab-32
• UniProt Protein Name: Ras-related protein Rab-32
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB32
• UniProt Entry Name: RAB32_HUMAN

NCBI Description

Small GTP-binding proteins of the RAB family, such as RAB32, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Aug 2009]

Uniprot Description

RAB32: Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein, monomeric; G protein; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 6q24.3

Cellular Component: phagocytic vesicle membrane; mitochondrion; membrane; early endosome; melanosome; phagocytic vesicle; trans-Golgi network

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; GTP-dependent protein binding

Biological Process: intracellular protein transport; antigen processing and presentation; metabolic process; Rab protein signal transduction