RAB14 recombinant protein

Recombinant Human RAB14

Cat. Num. AAA7614702

• Gene Names: RAB14; FBP; RAB-14
• Applications: Western Blot, ELISA
• Purity: Greater than 85% by SDS-PAGE gel analyses
• Synonyms: RAB14; Recombinant Human RAB14; FBP; RAB 14; Ras related protein Rab 14; RAB14 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85% by SDS-PAGE gel analyses
• Form/Format: Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose and 0.06% proclin, pH7.4
• Sequence Positions: 2-215

• Applicable Applications for RAB14 recombinant protein: Western Blot (WB), ELISA (EIA)
• Species: Human
• Tag: N-terminal His-IF2DI Tag
• Reconstitution: Centrifuge the vial at 10,000rpm for 1 minute, reconstitute at 200ug/ml in sterile distilled water
• Preparation and Storage: Store at -20 degree C for 12 months as lyophilized; 2-8 degree C for 1 month under sterile conditions after reconstitution

NCBI and Uniprot Product Information

• NCBI GI #: 19923483
• NCBI GeneID: 51552
• NCBI Accession #: NP_057406.2
• NCBI GenBank Nucleotide #: NM_016322.3
• UniProt Accession #: P61106; P35287; Q5JVD4; Q6Q7K5; Q969L0; Q9UI11; B3KR31
• Molecular Weight: 23,897 Da
• NCBI Official Full Name: ras-related protein Rab-14
• NCBI Official Synonym Full Names: RAB14, member RAS oncogene family
• NCBI Official Symbol: RAB14
• NCBI Official Synonym Symbols: FBP; RAB-14
• NCBI Protein Information: ras-related protein Rab-14; F protein-binding protein 1; bA165P4.3 (member RAS oncogene family); small GTP binding protein RAB14
• UniProt Protein Name: Ras-related protein Rab-14
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB14
• UniProt Entry Name: RAB14_HUMAN

NCBI Description

RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]

Uniprot Description

RAB14: a protein of the GTPase superfamily, Rab family. May be involved in vesicular trafficking and neurotransmitter release. Localized to the inner face of the cell membrane by a lipid-anchor.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 9q33.2

Cellular Component: Golgi apparatus; Golgi stack; cytoplasmic vesicle membrane; nuclear envelope-endoplasmic reticulum network; intracellular membrane-bound organelle; rough endoplasmic reticulum; lysosomal membrane; lysosome; early endosome; phagocytic vesicle; cytosol; Golgi membrane; trans-Golgi network transport vesicle; recycling endosome; phagocytic vesicle membrane; perinuclear region of cytoplasm; early endosome membrane; late endosome; plasma membrane; intracellular

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; myosin V binding

Biological Process: vesicle-mediated transport; intracellular protein transport; embryonic development; intracellular transport; fibroblast growth factor receptor signaling pathway; regulation of protein localization; metabolic process; Golgi to endosome transport; Rab protein signal transduction; endocytic recycling