RAB10 recombinant protein

Recombinant Human RAB10, Member RAS Oncogene Family

Cat. Num. AAA145756

• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: RAB10; Recombinant Human RAB10; Member RAS Oncogene Family; RAB10 Human; Member RAS Oncogene Family Human Recombinant; Ras-related GTP-binding protein RAB10; Ras-related protein Rab-10; Rab10; member RAS oncogene family; RAB10 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: The RAB10 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol 0.4M Urea.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MAKKTYDLLF KLLLIGDSGV GKTCVLFRFS DDAFNTTFIS TIGIDFKIKT VELQGKKIKL QIWDTAGQER FHTITTSYYR GAMGIMLVYD ITNGKSFENI SKWLRNIDEH ANEDVERMLL GNKCDMDDKR VVPKGKGEQI AREHGIRFFE TSAKANINIE KAFLTLAEDI LRKTPVKEPN SENVDISSGG GVTGWKSKCC.
• Sequence Length: 200

Related Product Information for RAB10 recombinant protein

Description: RAB10 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 220 amino acids (1-200) and having a molecular mass of 24.7 kDa. RAB10 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: RAB10, Member RAS Oncogene Family (RAB10) belongs to the Ras superfamily of small GTP-binding proteins. RAB10 is a key regulator of endocytic recycling, particularly in the basolateral recycling pathways of polarized epithelial cells. It is required for the recruitment of CNT-1 to endosomal membranes in the intestinal epithelium.

Product Categories/Family for RAB10 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Member RAS Oncogene Family

NCBI and Uniprot Product Information

• NCBI GI #: 256222019
• NCBI GeneID: 10890
• NCBI Accession #: NP_057215.3
• NCBI GenBank Nucleotide #: NM_016131.4
• UniProt Accession #: P61026; O88386; Q6IA52; Q9D7X6; Q9H0T3; D6W538
• Molecular Weight: 22,541 Da
• NCBI Official Full Name: ras-related protein Rab-10
• NCBI Official Synonym Full Names: RAB10, member RAS oncogene family
• NCBI Official Symbol: RAB10
• NCBI Protein Information: ras-related protein Rab-10; GTP-binding protein RAB10; ras-related GTP-binding protein
• UniProt Protein Name: Ras-related protein Rab-10
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB10
• UniProt Entry Name: RAB10_HUMAN

NCBI Description

RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

Uniprot Description

RAB10: a protein of the GTPase superfamily, Rab family. May be involved in vesicular trafficking and neurotransmitter release. Localized to the inner face of the cell membrane by a lipid-anchor.

Protein type: G protein, monomeric, Rab; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: Golgi apparatus; recycling endosome; endoplasmic reticulum membrane; phagocytic vesicle membrane; cytoplasmic vesicle membrane; focal adhesion; recycling endosome membrane; exocyst; plasma membrane; endosome membrane; trans-Golgi network; endosome

Molecular Function: GTPase activity; GDP binding; GTP binding; myosin V binding

Biological Process: metabolic process; establishment of neuroblast polarity; protein secretion; endosome transport; regulation of exocytosis; vesicle-mediated transport; intracellular protein transport; polarized epithelial cell differentiation; antigen processing and presentation; Golgi to plasma membrane transport; cellular response to insulin stimulus; axonogenesis; Golgi to plasma membrane protein transport; Rab protein signal transduction; vesicle docking during exocytosis