Quinolinate Phosphoribosyltransferase/QPRTase Recombinant Protein | QPRTase recombinant protein
Recombinant Human Quinolinate Phosphoribosyltransferase/QPRTase Protein (N-6His)
Gene Names
QPRT; QPRTase; HEL-S-90n
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Quinolinate Phosphoribosyltransferase/QPRTase; Recombinant Human Quinolinate Phosphoribosyltransferase/QPRTase Protein (N-6His); Nicotinate-Nucleotide Pyrophosphorylase [Carboxylating]; Quinolinate Phosphoribosyltransferase [Decarboxylating]; QAPRTase; QPRTase; QPRT; QPRTase recombinant protein
Host
E Coli
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Supplied as a 0.2 mum filtered solution of 20mM Tris HCl, 150mM NaCl, pH 8.0.
Sequence Positions
Met1-His297
Sequence Length
297
Species
Human
Endotoxin
<1.0 EU per ug as determined by LAL test.
Fusion Tag
N-6His
Preparation and Storage
Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Related Product Information for QPRTase recombinant protein
Nicotinate-Nucleotide Pyrophosphorylase (QPRT) belongs to the nadC/modD family. QPRT plays an improtant role in catabolism of quinolinate which acts as a potent endogenous exitotoxin to neurons. In addition, QPRT serves as an an intermediate in the Tryptophan-Nicotinamide Adenine Dinucleotide pathway. QPRT participates in some pathways including Cofactor biosynthesis, NAD(+) biosynthesis and the Nicotinate D-Ribonucleotide from Quinolinate. In addition, QPRT is involved in the catabolism of Quinolinic Acid (QA). The activity toward QA is slightly repressed by phosphoribosylpyrophosphate (PRPP) in both a competitive and a non-competitive manner.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
Molecular Mass: 33.0 kDa
Actual Protein Molecular Mass: 34 kDa
Actual Protein Molecular Mass: 34 kDa
NCBI Official Full Name
Quinolinate phosphoribosyltransferase
NCBI Official Synonym Full Names
quinolinate phosphoribosyltransferase
NCBI Official Symbol
QPRT
NCBI Official Synonym Symbols
QPRTase; HEL-S-90n
NCBI Protein Information
nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt Protein Name
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt Gene Name
QPRT
UniProt Synonym Gene Names
QAPRTase; QPRTase
NCBI Description
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Description
Involved in the catabolism of quinolinic acid (QA).
Research Articles on QPRTase
Similar Products
Product Notes
The QPRTase qprt (Catalog #AAA2553170) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Met1-His297. It is sometimes possible for the material contained within the vial of "Quinolinate Phosphoribosyltransferase/QPRTase, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
