QKI recombinant protein

Recombinant Human QKI

Cat. Num. AAA144865

• Gene Names: QKI; QK; Hqk; QK1; QK3; hqkI
• Purity: Greater than 85.0% as determined by SDS-PAGE.
• Synonyms: QKI; Recombinant Human QKI; QKI Human; QKI Human Recombinant; Hqk; hqkI; QK; QK1; QK3; Protein quaking; Quaking; QKI recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85.0% as determined by SDS-PAGE.
• Form/Format: QKI protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol, 2mM DTT.; Sterile Filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMVGEMET KEKPKPTPDY LMQLMNDKKL MSSLPNFCGI FNHLERLLDE EISRVRKDMY NDTLNGSTEK RSAELPDAVG PIVQLQEKLY VPVKEYPDFN FVGRILGPRG LTAKQLEAET GCKIMVRGKG SMRDKKKEEQ NRGKPNWEHL NEDLHVLITV EDAQNRAEIK LKRAVEEVKK LLVPAAEGED SLKKMQLMEL AILNGTYRDA NIKSPALAFS LAATAQAAPR IITGPAPVLP PAALRTPTPA GPTIMPLIRQ IQTAVMPNGT PHPTAAIVPP GPEAGLIYTP YEYPYTLAPA TSILEYPIEP SGVLGAVATK VRRHDMRVHP YQRIVTADRA ATGN
• Sequence Length: 333

Related Product Information for QKI recombinant protein

Description: LBH Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 128 amino acids (1-105 a.a) and having a molecular mass of 14.6kDa.LBH is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: KH Domain RNA Binding also known as QKI is a

Product Categories/Family for QKI recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 666637982
• NCBI GeneID: 9444
• NCBI Accession #: NP_001288014.1
• NCBI GenBank Nucleotide #: NM_001301085.1
• UniProt Accession #: Q96PU8; Q2I375; Q5MJQ1; Q969L9; Q96EJ3; Q96KA3; Q96PU6; Q96PU7; Q9P0X6; Q9P0X7; Q9P0X8; Q9P0X9
• Molecular Weight: 35,131 Da
• NCBI Official Full Name: protein quaking isoform 5
• NCBI Official Synonym Full Names: QKI, KH domain containing, RNA binding
• NCBI Official Symbol: QKI
• NCBI Official Synonym Symbols: QK; Hqk; QK1; QK3; hqkI
• NCBI Protein Information: protein quaking; RNA binding protein HQK; homolog of mouse quaking QKI (KH domain RNA binding protein); quaking homolog, KH domain RNA binding
• UniProt Protein Name: Protein quaking
• Protein Family: Protein quaking
• UniProt Gene Name: QKI
• UniProt Synonym Gene Names: HKQ; Hqk; HqkI
• UniProt Entry Name: QKI_HUMAN

NCBI Description

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Description

QKI: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor. 6 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: cytoplasm; nucleus

Molecular Function: mRNA binding; protein binding; SH3 domain binding

Biological Process: regulation of translation; myelination; muscle cell differentiation; mRNA transport; RNA splicing; long-chain fatty acid biosynthetic process; vasculogenesis; mRNA processing; spermatid development