Mouse protein tyrosine phosphatase, receptor type, Q ELISA Kit | PTPRQ elisa kit
Mouse Phosphotidylinositol phosphatase PTPRQ, PTPRQ ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PTPRQ: Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells. Defects in PTPRQ are the cause of deafness autosomal recessive type 84 (DFNB84). DFNB84 is a form of non- syndromic deafness characterized by progressive, sensorineural hearing loss and vestibular dysfunction. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
Protein type: Receptor protein phosphatase, tyrosine; Phosphatase, lipid; Membrane protein, integral; EC 3.1.3.48
Cellular Component: stereocilium bundle; membrane; integral to membrane
Molecular Function: protein tyrosine/threonine phosphatase activity; inositol-1,3,4-trisphosphate 4-phosphatase activity; hydrolase activity; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; protein tyrosine phosphatase activity; inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity; inositol bisphosphate phosphatase activity; inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity; JUN kinase phosphatase activity; transmembrane receptor protein phosphatase activity; phosphatidylinositol-4-phosphate phosphatase activity; 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity; NADP phosphatase activity; phosphoric monoester hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; inositol-4,5-bisphosphate 5-phosphatase activity; phosphohistidine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity
Biological Process: vestibular receptor cell morphogenesis; inner ear morphogenesis; dephosphorylation; regulation of fat cell differentiation; hemopoietic progenitor cell differentiation; protein amino acid dephosphorylation; neuromuscular process controlling balance; detection of mechanical stimulus involved in sensory perception of sound
Research Articles on PTPRQ
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Product Notes
The Mouse PTPRQ ptprq (Catalog #AAA9332631) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332631 ELISA Kit recognizes Mouse PTPRQ. It is sometimes possible for the material contained within the vial of "protein tyrosine phosphatase, receptor type, Q, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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