Receptor-type tyrosine-protein phosphatase N2 (Ptprn2) Recombinant Protein | Ptprn2 recombinant protein

Recombinant Mouse Receptor-type tyrosine-protein phosphatase N2 (Ptprn2)

Cat. Num. AAA957675

• Gene Names: Ptprn2; Phol; PTP-NP; IA2beta; phogrin; mKIAA0387; 4930425H11Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Receptor-type tyrosine-protein phosphatase N2 (Ptprn2); Recombinant Mouse Receptor-type tyrosine-protein phosphatase N2 (Ptprn2); Ptprn2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 28-600aa, Full Length of Mature Protein
• Sequence: RGRQLPGRLGCLFEDGLCGSLETCVNDGVFGRCQKVPVMDTYRYEVPPGALLHLKVTLQKLSRTGFTWQDDYTQRVIAQELANLPKAYLWHGEASGPARSLQQNADNEKWFSLEREVALAKTLRRYLPYLELLSQTPTANAHSRIDHETRPAKGEDSSPENILTYVAHTSALTYPPATRAKYPDNLLRPFSRLQPDELSPKVDGDIDKQKLIAALGAYTAQRLPGENDPEPRYLVHGSARAPRPFSATALSQRWPPPPGDAKDSPSMDDDTLLQSLLKDLQQNSEVDRLGPLKEEKADSVAGAIQSDPAEGSQESHGRGAEGQPREQTDAPETMLQDHRLSEVDDPVYKEVNRLSFQLGDLLKDYGSPLLPEGPLLEKSSREEIKKSEQPEEVLSSEEETAGVEHVRSRTYSKDLFERKPNSEPQPRRLEDQFQNRAPELWEDEESLKLAAQGPPSGGLQLEVQPSEEQQGYILTGNNPLSPEKGKQLMDQVAHILRVPSSFFADIKVLGPAVTFKVSANIQNMTTADVIKAAADNKDQLEKATGLTILQSGIRPKGKLKLLPHQEEQEDSTK
• Sequence Length: –

• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-Page

Related Product Information for Ptprn2 recombinant protein

This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN
IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

NCBI and Uniprot Product Information

• NCBI GI #: 226052731
• NCBI GeneID: 19276
• NCBI Accession #: NP_035345.2
• NCBI GenBank Nucleotide #: NM_011215.2
• UniProt Accession #: P80560; O09134; P70328; Q1RLJ1
• Molecular Weight: 65.7 kDa
• NCBI Official Full Name: receptor-type tyrosine-protein phosphatase N2
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type, N polypeptide 2
• NCBI Official Symbol: Ptprn2
• NCBI Official Synonym Symbols: Phol; PTP-NP; IA2beta; phogrin; mKIAA0387; 4930425H11Rik
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase N2
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase N2
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: Ptprn2
• UniProt Synonym Gene Names: PTP-NP

Uniprot Description

Plays a role in vesicle-mediated secretory processes (PubMed:21732083). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:21732083). Plays a role in insulin secretion in response to glucose stimuli (PubMed:15220191, PubMed:16418280, PubMed:21732083). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (PubMed:16269463). Required to maintain normal levels of renin expression and renin release (PubMed:19019914). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (PubMed:12364328). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments ().