Receptor-type tyrosine-protein phosphatase-like N (Ptprn) Recombinant Protein | Ptprn\r recombinant protein

Recombinant Mouse Receptor-type tyrosine-protein phosphatase-like N (Ptprn), partial

Cat. Num. AAA1300651

• Gene Names: Ptprn; IA-2; mIA-A; mKIAA4064
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Receptor-type tyrosine-protein phosphatase-like N (Ptprn); Recombinant Mouse Receptor-type tyrosine-protein phosphatase-like N (Ptprn); partial; Ptprn\r recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 38-575
• Sequence: ISA HGCLFDRRLC SHLEVCIQDG LFGQCQAGVG QARPLLQVTS PVLQRLQGVL RQLMSQGLSW HDDLTQHVIS QEMERIPRLR PPEPHPRDRS GLVPRKPGPA GELLTQGNPT GSSPAAQGFP RPAGGRSWGG SPLSSLQAEL LPPLLEHLLM PPQPPHPALT YEPALLQPYL FHQFGSRDGS RGSESSSGVV GVGHLSKAEG PALFSRSASK AILGTHSGHS FGDLTGPSPA QLFQDSGLLY MAQELPVPGR ARAPRLPENG GNRAEDSSEG HEEEVLGGRG EKSPPQAAQP ELSLQRLTAV LAGYGVELRQ LTPEQFSTLL TLLQLLPKGT GRNLEGAVNV GGADVKKTIQ QMQRGDPAEA LPPTPSLPGY LTASPASSEV QQVLSPGFPE PPHTPSPLGS SSVLLEKKSP LGQSQPTVVG RPSARPSAEE YGYIVTDQKP LSLVAGVRLL EILAEHVHMS SGSFINISVV GPAVTFRIRH NEQNLSLADV TQQAGLVKSE LEAQTGLQIL QTGVGQREEA AEVLPRQAHG ISPMR
• Sequence Length: 538

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Ptprn\r recombinant protein

This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.

NCBI and Uniprot Product Information

• NCBI GI #: 341941773
• NCBI GeneID: 19275
• UniProt Accession #: Q60673; Q62129; E9Q746
• Molecular Weight: 106,083 Da
• NCBI Official Full Name: Receptor-type tyrosine-protein phosphatase-like N
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type, N
• NCBI Official Symbol: Ptprn
• NCBI Official Synonym Symbols: IA-2; mIA-A; mKIAA4064
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase-like N
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase-like N
• UniProt Gene Name: Ptprn
• UniProt Synonym Gene Names: Ptp35; R-PTP-N; ICA512-NTF; ICA512-TMF; ICA512-CCF

Uniprot Description

Plays a role in vesicle-mediated secretory processes (PubMed:21732083). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:15939893, PubMed:21732083). Plays a role in insulin secretion in response to glucose stimuli (PubMed:12031972, PubMed:21732083). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (PubMed:16269463). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (PubMed:16269463). Seems to lack intrinsic enzyme activity (PubMed:7980563, PubMed:8878556). Required to maintain normal levels of renin expression and renin release (PubMed:19019914). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (PubMed:12364328).