Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) Recombinant Protein | PTPN11 recombinant protein

Recombinant Chicken Tyrosine-protein phosphatase non-receptor type 11 (PTPN11), partial

• Gene Names: PTPN11; SYP
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Tyrosine-protein phosphatase non-receptor type 11 (PTPN11); Recombinant Chicken Tyrosine-protein phosphatase non-receptor type 11 (PTPN11); partial; PTPN11 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 593

• Species: Chicken
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for PTPN11 recombinant protein

This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

NCBI and Uniprot Product Information

• NCBI GI #: 45384450
• NCBI GeneID: 395815
• NCBI Accession #: NP_990299.1
• NCBI GenBank Nucleotide #: NM_204968.1
• UniProt Accession #: Q90687
• Molecular Weight: 67,983 Da
• NCBI Official Full Name: tyrosine-protein phosphatase non-receptor type 11
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, non-receptor type 11
• NCBI Official Symbol: PTPN11
• NCBI Official Synonym Symbols: SYP
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 11
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 11
• Protein Family: Tyrosine-protein phosphatase non-receptor
• UniProt Gene Name: PTPN11
• UniProt Synonym Gene Names: cSH-PTP2

Uniprot Description

This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (). May play a positive role during the stages of erythroid cell proliferation (PubMed:8921851).