Testing Data
Pleiotrophin Recombinant Protein | PTN recombinant protein
Human Pleiotrophin
Gene Names
PTN; HARP; HBNF; HBGF8; NEGF1
Reactivity
Species Reactivity: HumanCross Reactivity: Bacteria, Mouse, Rat
Purity
Above 98% as determined by SDS-PAGE Analysis.
Synonyms
Pleiotrophin; Human Pleiotrophin; Recombinant Human Pleiotrophin; PTN recombinant protein
Host
E Coli
Reactivity
Species Reactivity: Human
Cross Reactivity: Bacteria, Mouse, Rat
Cross Reactivity: Bacteria, Mouse, Rat
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Sequence
GKKEKPEKK VKKSDCGEW QWSVCVPTS GDCGLGTRE GTRTGAECK QTMKTQRCK IPCNWKKQF GAECKYQFQ AWGECDLNT ALKTRTGSL KRALHNAEC QKTVTISKP CGKLTKPKP QAESKKKKK EGKKQEKML D
Cell Type
Neurons
Preparation and Storage
At -20 degree C
Testing Data
Testing Data
Related Product Information for PTN recombinant protein
Pleiotrophin and Midkine are structurally related heparin-binding neurotrophic factors, whose expression is developmentally regulated. The expression pattern of these neurotrophic factors suggests function in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm epithelial interaction. The expression of PTN increases during the process of brain embryogenesis and reaches maximum levels at time of birth. The physiological roles of PTN and Midkine are largely unknown, but these neurotrophins have been implicated in the pathogenesis of neuroblastomas. Recombinant human Pleiotrophin is a 15.4 kDa protein containing 136 amino acid residues and five intra-molecular disulfide bonds.
Product Categories/Family for PTN recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
18,942 Da
NCBI Official Full Name
Pleiotrophin
NCBI Official Synonym Full Names
pleiotrophin
NCBI Official Symbol
PTN
NCBI Official Synonym Symbols
HARP; HBNF; HBGF8; NEGF1
NCBI Protein Information
pleiotrophin; HBBM; OSF-1; HB-GAM; HBGF-8; HBNF-1; osteoblast-specific factor 1; heparin-binding brain mitogen; heparin binding growth factor 8; heparin-binding growth factor 8; heparin affin regulatory protein; neurite growth-promoting factor 1; heparin-binding growth-associated molecule; heparin-binding neurite outgrowth-promoting factor 1; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
UniProt Protein Name
Pleiotrophin
Protein Family
UniProt Gene Name
PTN
UniProt Synonym Gene Names
HBNF1; NEGF1; PTN; HBBM; HBGF-8; HB-GAM; HBNF-1; OSF-1
UniProt Entry Name
PTN_HUMAN
Uniprot Description
PTN: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. Belongs to the pleiotrophin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7q33
Cellular Component: extracellular space; endoplasmic reticulum
Molecular Function: heparin binding; growth factor activity; protein phosphatase inhibitor activity
Biological Process: nervous system development; positive regulation of cell division; negative regulation of catalytic activity; positive regulation of cell proliferation; learning; transmembrane receptor protein tyrosine phosphatase signaling pathway; bone mineralization
Research Articles on PTN
Similar Products
Product Notes
The PTN ptn (Catalog #AAA695859) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human Pleiotrophin reacts with Species Reactivity: Human Cross Reactivity: Bacteria, Mouse, Rat and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: GKKEKPEKK VKKSDCGEW QWSVCVPTS GDCGLGTRE GTRTGAECK QTMKTQRCK IPCNWKKQF GAECKYQFQ AWGECDLNT ALKTRTGSL KRALHNAEC QKTVTISKP CGKLTKPKP QAESKKKKK EGKKQEKML D. It is sometimes possible for the material contained within the vial of "Pleiotrophin, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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