26S protease regulatory subunit 6B (Psmc4) Recombinant Protein | Psmc4 recombinant protein

Recombinant Mouse 26S protease regulatory subunit 6B (Psmc4)

Cat. Num. AAA961486

• Gene Names: Psmc4; CIP21; MIP224
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: 26S protease regulatory subunit 6B (Psmc4); Recombinant Mouse 26S protease regulatory subunit 6B (Psmc4); Psmc4 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-418, Full length protein
• Sequence: MEEIGILVEKIQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
• Sequence Length: 418

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Psmc4 recombinant protein

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP
ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.

NCBI and Uniprot Product Information

• NCBI GI #: 124248577
• NCBI GeneID: 23996
• NCBI Accession #: NP_036004.2
• NCBI GenBank Nucleotide #: NM_011874.2
• UniProt Accession #: P54775; Q6ZWN9
• Molecular Weight: 47,408 Da
• NCBI Official Full Name: 26S proteasome regulatory subunit 6B
• NCBI Official Synonym Full Names: proteasome (prosome, macropain) 26S subunit, ATPase, 4
• NCBI Official Symbol: Psmc4
• NCBI Official Synonym Symbols: CIP21; MIP224
• NCBI Protein Information: 26S proteasome regulatory subunit 6B
• UniProt Protein Name: 26S proteasome regulatory subunit 6B
• Protein Family: 26S protease regulatory
• UniProt Gene Name: Psmc4
• UniProt Synonym Gene Names: Tbp7; TBP-7

Uniprot Description

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.