Fibronectin, Hamster Protein | Fn1 protein
Fibronectin, Hamster
~95% (SDS-PAGE)
~95% (SDS-PAGE)
NCBI and Uniprot Product Information
Uniprot Description
FN1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. 15 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Cell adhesion
Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; apical plasma membrane; fibrinogen complex; ER-Golgi intermediate compartment; extracellular region; basement membrane; basal lamina
Molecular Function: heparin binding; integrin binding; protein binding; protease activator activity; protease binding; mercury ion binding
Biological Process: integrin activation; extracellular matrix organization and biogenesis; wound healing; positive regulation of chemotaxis; cell-matrix adhesion; positive regulation of axon extension; glial cell migration; regulation of cell shape; cell activation; cell-substrate junction assembly; acute-phase response; calcium-independent cell-matrix adhesion; peptide cross-linking; angiogenesis; cell adhesion; negative regulation of apoptosis; positive regulation of cell migration
Similar Products
Product Notes
The Fibronectin, Hamster fn1 (Catalog #AAA634492) is a Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Fibronectin, Hamster, Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
