Thyrotropin Releasing Hormone (TRH) Small Molecule | TRH small molecule

OVA Conjugated Thyrotropin Releasing Hormone (TRH)

Cat. Num. AAA2086307

• Gene Names: TRH; TRF; Pro-TRH
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: Thyrotropin Releasing Hormone (TRH); OVA Conjugated Thyrotropin Releasing Hormone (TRH); TRF; Thyrotropin-Releasing Factor; Thyroliberin; Protirelin; Pro-tirelin; Prothyroliberin; TSH-releasing factor; TRH small molecule

• Host: Protein Conjugation
• Purity/Purification: > 90%
• Form/Format: Freeze-dried powder
• Sequence Length: 242

• Applicable Applications for TRH small molecule: Immunogen, SDS-PAGE, Western Blot (WB)
• Buffer Formulation: PBS, pH7.4.
• Organism Species: Mouse
• Usage: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Sequence Information

Testing Data

Testing Data

Product Categories/Family for TRH small molecule

Conjugated small molecules

NCBI and Uniprot Product Information

• NCBI GI #: 6005920
• NCBI GeneID: 7200
• NCBI Accession #: NP_009048.1
• NCBI GenBank Nucleotide #: NM_007117.4
• UniProt Accession #: P20396; Q2TB83; B2R8R1
• Molecular Weight: 27,404 Da
• NCBI Official Full Name: thyrotropin releasing hormone preproprotein
• NCBI Official Synonym Full Names: thyrotropin releasing hormone
• NCBI Official Symbol: TRH
• NCBI Official Synonym Symbols: TRF; Pro-TRH
• NCBI Protein Information: thyrotropin releasing hormone
• UniProt Protein Name: Pro-thyrotropin-releasing hormone
• Protein Family: Thyrotropin-releasing hormone
• UniProt Gene Name: TRH
• UniProt Synonym Gene Names: Pro-TRH; TRH; TRF

NCBI Description

This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]

Uniprot Description

TRH: Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes. Belongs to the TRH family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: extracellular region; nucleus; plasma membrane; secretory granule

Biological Process: cell-cell signaling; eating behavior; histamine metabolic process; negative regulation of glutamate secretion; positive regulation of gamma-aminobutyric acid secretion; positive regulation of insulin secretion; signal transduction

Disease: Thyrotropin-releasing Hormone Deficiency