C-Type Natriuretic Peptide (CNP) Small Molecule | CNP small molecule

OVA Conjugated C-Type Natriuretic Peptide (CNP)

Cat. Num. AAA2086254

• Gene Names: NPPC; CNP; CNP2
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: C-Type Natriuretic Peptide (CNP); OVA Conjugated C-Type Natriuretic Peptide (CNP); NPPC; Natriuretic Peptide Precursor C; CNP small molecule

• Host: Protein Conjugation
• Purity/Purification: > 90%
• Form/Format: Freeze-dried powder
• Sequence Length: 126

• Applicable Applications for CNP small molecule: Immunogen, SDS-PAGE, Western Blot (WB)
• Buffer Formulation: PBS, pH7.4.
• Organism Species: Mouse
• Usage: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Sequence Information

Product Categories/Family for CNP small molecule

Conjugated small molecules

NCBI and Uniprot Product Information

• NCBI GI #: 13249346
• NCBI GeneID: 4880
• NCBI Accession #: NP_077720.1
• NCBI GenBank Nucleotide #: NM_024409.3
• UniProt Accession #: P23582; Q4ZG41
• Molecular Weight: 13,246 Da
• NCBI Official Full Name: C-type natriuretic peptide preproprotein
• NCBI Official Synonym Full Names: natriuretic peptide C
• NCBI Official Symbol: NPPC
• NCBI Official Synonym Symbols: CNP; CNP2
• NCBI Protein Information: C-type natriuretic peptide
• UniProt Protein Name: C-type natriuretic peptide
• Protein Family: 2',3'-cyclic-nucleotide 3'-phosphodiesterase
• UniProt Gene Name: NPPC
• UniProt Synonym Gene Names: CNP2

NCBI Description

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]

Uniprot Description

NPPC: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.

Protein type: Hormone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: extracellular region

Molecular Function: receptor binding

Biological Process: cGMP biosynthetic process; negative regulation of meiotic cell cycle; receptor guanylyl cyclase signaling pathway; regulation of cAMP metabolic process; regulation of cGMP metabolic process