Mouse protein arginine methyltransferase 6 ELISA Kit | PRMT6 elisa kit

Mouse Protein arginine N-methyltransferase 6, PRMT6 ELISA Kit

Cat. Num. AAA9322638

• Gene Names: Prmt6; Hrmt1l6; AW124876; BB233495
• Reactivity: Mouse
• Synonyms: protein arginine methyltransferase 6; Mouse Protein arginine N-methyltransferase 6; PRMT6 ELISA Kit; Mouse Protein arginine N-methyltransferase 6 (PRMT6) ELISA kit; FLJ10559; FLJ51477; HRMT1L6; HMT1 hnRNP methyltransferase-like 6; protein arginine N-methyltransferase 6; PRMT6 elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 126432554
• NCBI GeneID: 99890
• NCBI Accession #: NP_849222.3
• NCBI GenBank Nucleotide #: NM_178891.5
• UniProt Accession #: Q6NZB1; Q3TA42; Q8BN52; Q8BSC2; Q8R5D7
• Molecular Weight: 41,866 Da
• NCBI Official Full Name: protein arginine N-methyltransferase 6
• NCBI Official Synonym Full Names: protein arginine N-methyltransferase 6
• NCBI Official Symbol: Prmt6
• NCBI Official Synonym Symbols: Hrmt1l6; AW124876; BB233495
• NCBI Protein Information: protein arginine N-methyltransferase 6; HMT1 hnRNP methyltransferase-like 6; histone-arginine N-methyltransferase PRMT6
• UniProt Protein Name: Protein arginine N-methyltransferase 6
• Protein Family: Protein arginine N-methyltransferase
• UniProt Gene Name: Prmt6
• UniProt Synonym Gene Names: Hrmt1l6
• UniProt Entry Name: ANM6_MOUSE

Uniprot Description

PRMT6: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). It thereby acts as a transcription corepressor of various genes such as HOXA2. Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to stimulate the polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC). Belongs to the protein arginine N-methyltransferase family. PRMT6 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase, protein arginine; EC 2.1.1.125; Methyltransferase

Cellular Component: nucleus; cytosol

Molecular Function: methyltransferase activity; trimethylamine methyltransferase activity; monomethylamine methyltransferase activity; RNA methyltransferase activity; tRNA (cytosine)-methyltransferase activity; rRNA (cytosine-C5-967)-methyltransferase activity; rRNA (uridine) methyltransferase activity; N-methyltransferase activity; tRNA (guanine) methyltransferase activity; rRNA (adenine-N6,N6-)-dimethyltransferase activity; arginine N-methyltransferase activity; selenocysteine methyltransferase activity; protein-arginine N-methyltransferase activity; methanol-specific methylcobalamin:coenzyme M methyltransferase activity; tRNA (guanine-N2-)-methyltransferase activity; dimethylamine methyltransferase activity; protein methyltransferase activity; 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; hydroxyneurosporene-O-methyltransferase activity; transferase activity; rRNA (uridine-2'-O-)-methyltransferase activity; tRNA (uracil) methyltransferase activity; rRNA (adenine) methyltransferase activity; chromatin binding; C-methyltransferase activity; cobalt-precorrin-6B C5-methyltransferase activity; cobalt-precorrin-3 C17-methyltransferase activity; 1-phenanthrol methyltransferase activity; histone binding; S-methyltransferase activity; lysine N-methyltransferase activity; DNA-methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; tRNA (cytosine-5-)-methyltransferase activity; tRNA (adenine)-methyltransferase activity; C-terminal protein carboxyl methyltransferase activity; rRNA (cytosine) methyltransferase activity; cobalt-precorrin-7 C15-methyltransferase activity; protein-arginine N5-methyltransferase activity; rRNA methyltransferase activity; histone methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; histone-arginine N-methyltransferase activity; protein-leucine O-methyltransferase activity; demethylmenaquinone methyltransferase activity; rRNA (adenine-N6-)-methyltransferase activity; tRNA methyltransferase activity; rRNA (guanine) methyltransferase activity; methylarsonite methyltransferase activity; mRNA methyltransferase activity; methylamine-specific methylcobalamin:coenzyme M methyltransferase activity; tRNA (guanine-N1-)-methyltransferase activity; cobalt-precorrin-5B C1-methyltransferase activity; protein-lysine N-methyltransferase activity; O-methyltransferase activity; tRNA (adenine-N1-)-methyltransferase activity; tRNA (adenine-57, 58-N(1)-) methyltransferase activity

Biological Process: histone methylation; methylation; transcription, DNA-dependent; protein amino acid methylation; regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; chromatin modification; negative regulation of transcription, DNA-dependent; cell growth; DNA repair; response to DNA damage stimulus