cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) Recombinant Protein | PRKAR2B recombinant protein
Recombinant Bovine cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B); Recombinant Bovine cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B); PRKAR2B recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
2-418, Full length protein
Sequence
SIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQEENERKGTARFGHEGRTWGDAGAAGGGGTPSKGVNFAEEPRHSDSENGEEEEEEAADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA
Sequence Length
417
Species
Bovine
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for PRKAR2B recombinant protein
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This protein is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
46,336 Da
NCBI Official Full Name
cAMP-dependent protein kinase type II-beta regulatory subunit
NCBI Official Synonym Full Names
protein kinase cAMP-dependent type II regulatory subunit beta
NCBI Official Symbol
PRKAR2B
NCBI Protein Information
cAMP-dependent protein kinase type II-beta regulatory subunit
UniProt Protein Name
cAMP-dependent protein kinase type II-beta regulatory subunit
Protein Family
UniProt Gene Name
PRKAR2B
Uniprot Description
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Research Articles on PRKAR2B
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Product Notes
The PRKAR2B prkar2b (Catalog #AAA950499) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-418, Full length protein. The amino acid sequence is listed below: SIEIPAGLTE LLQGFTVEVL RHQPADLLEF ALQHFTRLQE ENERKGTARF GHEGRTWGDA GAAGGGGTPS KGVNFAEEPR HSDSENGEEE EEEAADAGAF NAPVINRFTR RASVCAEAYN PDEEEDDAES RIIHPKTDDQ RNRLQEACKD ILLFKNLDPE QMSQVLDAMF EKLVKEGEHV IDQGDDGDNF YVIDRGTFDI YVKCDGVGRC VGNYDNRGSF GELALMYNTP RAATITATSP GALWGLDRVT FRRIIVKNNA KKRKMYESFI ESLPFLKSLE VSERLKVVDV IGTKVYNDGE QIIAQGDSAD SFFIVESGEV KITMKRKGKS EVEENGAVEI ARCSRGQYFG ELALVTNKPR AASAHAIGTV KCLAMDVQAF ERLLGPCMEI MKRNIATYEE QLVALFGTNM DIVEPTA. It is sometimes possible for the material contained within the vial of "cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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