cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) Recombinant Protein | PRKAR1A recombinant protein

Recombinant Pig cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A)

Cat. Num. AAA965827

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A); Recombinant Pig cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A); PRKAR1A recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-380, Full length protein
• Sequence: MASGSTASEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKASARADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGNDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV
• Sequence Length: 380

• Species: Sus scrofa (Pig)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for PRKAR1A recombinant protein

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed.

NCBI and Uniprot Product Information

• NCBI GI #: 47522874
• NCBI GeneID: 397091
• NCBI Accession #: NP_999191.1
• NCBI GenBank Nucleotide #: NM_214026.1
• UniProt Accession #: P07802
• Molecular Weight: 42,922 Da
• NCBI Official Full Name: cAMP-dependent protein kinase type I-alpha regulatory subunit
• NCBI Official Symbol: PRKAR1A
• NCBI Protein Information: cAMP-dependent protein kinase type I-alpha regulatory subunit
• UniProt Protein Name: cAMP-dependent protein kinase type I-alpha regulatory subunit
• Protein Family: cAMP-dependent protein kinase
• UniProt Gene Name: PRKAR1A

Uniprot Description

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.