Factor X Active Protein | F10 active protein

Factor X protein

Cat. Num. AAA537563

• Gene Names: F10; fX; Cf10
• Purity: > 98%
• Synonyms: Factor X; Factor X protein; Complement Factor X protein; F10 active protein

• Host: Prepared from human serum/plasma
• Purity/Purification: > 98%
• Form/Format: Supplied as a liquid in 50% glycerol.
• Concentration: 10.0mg/ml (varies by lot)
• Sequence Length: 1

• Species: Human
• Grade: Ultra Pure
• Protein Type: Native
• Bioactivity: 115 units/mg protein - Specific activity is determined by Factor X clotting assay. One unit is equivalent to the Factor X activity in one milliliter of normal plasma.
• Specific Activity: 103 U/mg
• Biohazard Information: Although the starting material was test prior to initiation of the manufacturing process and was found negative or non-reactive for anti-HIV-1/2, HIV-1 RNA, HBsAg, STS, anti-HCV, HCV RNA, anti-HBcore and ant-HTLV 1&2, caution should be used when handling this material.
• Biological Significance: Factor X is a vitamin K-dependent protein zymogen which is synthesized in the liver and circulates in plasma as a two chain molecule linked by a disulfide bond. Prior to secretion into plasma, post-translational modifications produce 11 gamma-carboxyglutamic acid (gla) residues and a single b-hydroxyaspartic acid residue, which are located within the NH2-terminal light chain. The light chain also contains two epidermal growth factor (EGF) homology domains.
• Preparation and Storage: Ships on dry ice. Upon receipt store at -20°C.

Related Product Information for F10 active protein

Purified native Human Factor X protein

Product Categories/Family for F10 active protein

Proteases; Inhibitors; & Enzymes; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 4322473
• NCBI GeneID: 14058
• Molecular Weight: 58.9 kDa
• NCBI Official Full Name: factor X, partial
• NCBI Official Synonym Full Names: coagulation factor X
• NCBI Official Symbol: F10
• NCBI Official Synonym Symbols: fX; Cf10
• NCBI Protein Information: coagulation factor X
• UniProt Protein Name: Coagulation factor X
• Protein Family: Factor X-activator
• UniProt Gene Name: F10
• UniProt Entry Name: FA10_MOUSE

NCBI Description

This gene encodes factor X, a component of both the intrinsic and extrinsic blood coagulation pathways. The encoded protein is a zymogen that undergoes further processing in a vitamin K-dependent manner to generate mature factor X, a heterodimer comprised of disulfide-linked heavy and light chains. The mature factor X is proteolytically activated either by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway) to form factor Xa serine endopeptidase. Activated factor Xa catalyzes the conversion of prothrombin to thrombin. A complete lack of the encoded protein is fatal to mice. A severe deficiency of the encoded protein in mice causes age-dependent iron deposition and cardiac fibrosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Uniprot Description

F10: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Defects in F10 are the cause of factor X deficiency (FA10D). A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. Belongs to the peptidase S1 family.

Protein type: Secreted, signal peptide; Secreted; EC 3.4.21.6; Protease; Motility/polarity/chemotaxis; Lipid-binding

Cellular Component: membrane; intracellular membrane-bound organelle; extracellular region

Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; phospholipid binding; calcium ion binding; catalytic activity

Biological Process: positive regulation of protein kinase B signaling cascade; hemostasis; proteolysis; blood coagulation