Protein regulator of cytokinesis 1 (Prc1) Recombinant Protein | Prc1 recombinant protein
Recombinant Mouse Protein regulator of cytokinesis 1 (Prc1)
Gene Names
Prc1; D7Ertd348e
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Protein regulator of cytokinesis 1 (Prc1); Recombinant Mouse Protein regulator of cytokinesis 1 (Prc1); Prc1 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-603, Full length protein
Sequence
MRRSEVLADESITCLQKALTHLREIWELIGIPEEQRLQRTEVVKKHIKDLLDRMIAEEESLRERLLKSISICQKELSTLCSELQVKPFQEEKDTTILQLEKDLRTQVELMRKQKKERKQELKLLQEQEQELRDILCMPPCDVDSTSVPTLEELKLFRQRVATLRETKESRREEFVNIKKQIILCMEELEHSPDTSFERDVVCEDESAFCLSLENIATLQKLLKQLEMKKSQNEAECEGLRTQIRELWDRLQIPEEEREPVEAIMTGSKTKIRNALKLEVDRLEELKMQNIKQVIEKIRVELAQFWDQCFYSQEQRQAFAPYYSEDYTENLLHLHDAEIVRLRNYYDVHKELFQGVQKWEESWKLFLEFERKASDPGRFTNRGGNLLKEEKERAKLQKTLPKLEEELKARIEQWEQEHSTAFVVNGQKFMEYVTEQWELHRLEKERAKQERQLKNKKQTEAEMLYGSTPRTPSKRPGQTPKKSGKMNTTTMSSATPNSSIRPVFGGSVYRSPMSRLPPSGSKSVVTSLCSGKKTPRAAQLRANKENLDLNGSILSGGYPGSTPLQHNCSIKSVASTYSEFSRELSKASRSDATSRILNSTNIQS
Sequence Length
603
Species
Mouse
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Prc1 recombinant protein
This gene encodes a protein that is involved in cytokinesis. The encoded protein is at high level during S and G2
M and drop dramatically after cell exit mitosis and enter G1. It is located in the nucleus during interphase, and becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.
M and drop dramatically after cell exit mitosis and enter G1. It is located in the nucleus during interphase, and becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
70,290 Da
NCBI Official Full Name
protein regulator of cytokinesis 1 isoform 2
NCBI Official Synonym Full Names
protein regulator of cytokinesis 1
NCBI Official Symbol
Prc1
NCBI Official Synonym Symbols
D7Ertd348e
NCBI Protein Information
protein regulator of cytokinesis 1
UniProt Protein Name
Protein regulator of cytokinesis 1
Protein Family
UniProt Gene Name
Prc1
Uniprot Description
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression.
Research Articles on Prc1
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Product Notes
The Prc1 prc1 (Catalog #AAA1336659) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-603, Full length protein. The amino acid sequence is listed below: MRRSEVLADE SITCLQKALT HLREIWELIG IPEEQRLQRT EVVKKHIKDL LDRMIAEEES LRERLLKSIS ICQKELSTLC SELQVKPFQE EKDTTILQLE KDLRTQVELM RKQKKERKQE LKLLQEQEQE LRDILCMPPC DVDSTSVPTL EELKLFRQRV ATLRETKESR REEFVNIKKQ IILCMEELEH SPDTSFERDV VCEDESAFCL SLENIATLQK LLKQLEMKKS QNEAECEGLR TQIRELWDRL QIPEEEREPV EAIMTGSKTK IRNALKLEVD RLEELKMQNI KQVIEKIRVE LAQFWDQCFY SQEQRQAFAP YYSEDYTENL LHLHDAEIVR LRNYYDVHKE LFQGVQKWEE SWKLFLEFER KASDPGRFTN RGGNLLKEEK ERAKLQKTLP KLEEELKARI EQWEQEHSTA FVVNGQKFME YVTEQWELHR LEKERAKQER QLKNKKQTEA EMLYGSTPRT PSKRPGQTPK KSGKMNTTTM SSATPNSSIR PVFGGSVYRS PMSRLPPSGS KSVVTSLCSG KKTPRAAQLR ANKENLDLNG SILSGGYPGS TPLQHNCSIK SVASTYSEFS RELSKASRSD ATSRILNSTN IQS. It is sometimes possible for the material contained within the vial of "Protein regulator of cytokinesis 1 (Prc1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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