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Cyclophilin A Recombinant Protein | PPIA recombinant protein
Cyclophilin A Protein, Mouse, Recombinant (His Tag)
Gene Names
Ppia; Cphn; CypA; CyP-18; 2700098C05
Purity
>97% as determined by SDS-PAGE
Synonyms
Cyclophilin A; Cyclophilin A Protein; Mouse; Recombinant (His Tag); Mouse Cyclophilin A/PPIA/CYPA Protein (His Tag); 2700098C05 Protein; Cphn Protein; CyP-18 Protein; CypA Protein; peptidylprolyl isomerase A (cyclophilin A); PPIA recombinant protein
Host
E Coli
Purity/Purification
>97% as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH7.4, 10% glycerol. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Sequence
Met1-Leu164
Species
Mouse
Predicted N Terminal
Met
Tag
C-His
Protein Construction
A DNA sequence encoding the mouse PPIA (NP_032933.1)(Met 1-Leu 164) was expressed, with a polyhistide tag at the C-terminus.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
SDS-Page
SDS-Page
Related Product Information for PPIA recombinant protein
Background: Peptidyl-prolyl cis-trans isomerase A, also known as PPIase A, Rotamase A, Cyclophilin A, Cyclosporin A-binding protein, PPIA and CYPA, is a cytoplasm protein that belongs to the cyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins (CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, suggesting that they influence the conformation of proteins in cells. PPIA/Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIA/Cyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli, and could thus contribute to atherosclerosis. It is not essential for mammalian cell viability. PPIA/Cyclophilin A can interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.
Product Categories/Family for PPIA recombinant protein
References
Haendler B., et al.,(1987), Complementary DNA for human T-cell cyclophilin. EMBO J. 6:947-950.Haendler B., et al., (1990), Characterization of the human cyclophilin gene and of related processed pseudogenes.Eur. J. Biochem. 190:477-482.Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
17,971 Da
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase A
NCBI Official Synonym Full Names
peptidylprolyl isomerase A
NCBI Official Symbol
Ppia
NCBI Official Synonym Symbols
Cphn; CypA; CyP-18; 2700098C05
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase A
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase A
Protein Family
UniProt Gene Name
Ppia
UniProt Synonym Gene Names
PPIase A
UniProt Entry Name
PPIA_MOUSE
Uniprot Description
PPIA: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Interacts with HIV-1 Capsid protein. Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase. Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
Protein type: Cyclophilin; EC 5.2.1.8; Isomerase; RNA-binding
Cellular Component: cytosol; extracellular space; focal adhesion; membrane; myelin sheath; nucleus
Molecular Function: cyclosporin A binding; peptidyl-prolyl cis-trans isomerase activity; protein binding
Biological Process: neuron differentiation; positive regulation of protein secretion; positive regulation of viral genome replication; protein peptidyl-prolyl isomerization; regulation of viral genome replication
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Product Notes
The PPIA ppia (Catalog #AAA8122666) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Met1-Leu16 4. It is sometimes possible for the material contained within the vial of "Cyclophilin A, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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